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A comprehensive history of cancer - one of the greatest enemies of medical progress - and an insight into its effects and potential cures, by a leading expert on the illness.In The Emperor of All Maladies, Siddhartha Mukherjee, doctor, researcher and award-winning science writer, examines cancer with a cellular biologist's precision, a historian's perspective, and a biographer's passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with - and perished from - for more than five thousand years.The story of cancer is a story of human ingenuity, resilience and perseverance, but also of hubris, arrogance and misperception, all leveraged against a disease that, just three decades ago, was thought to be easily vanquished in an all-out 'war against cancer'. Mukherjee recounts centuries of discoveries, setbacks, victories and deaths, told through the eyes of predecessors and peers, training their wits against an infinitely resourceful adversary.From the Persian Queen Atossa, whose Greek slave cut off her malignant breast, to the nineteeth-century recipient of primitive radiation and chemotherapy and Mukherjee's own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through toxic, bruising, and draining regimes to survive and to increase the store of human knowledge.Riveting and magesterial, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments and a brilliant new perspective on the way doctors, scientists, philosophers and lay people have observed and understood the human body for millennia.
Siddhartha Mukherjee (Author), Stephen Hoye (Narrator)
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The origin of asthma, autism, Alzheimer's, allergies, cancer, heart disease, obesity, and even some kinds of depression is now clear. Award-winning researcher on the microbiome, professor Rodney Dietert presents a new paradigm in human biology that has emerged in the midst of the ongoing global epidemic of noncommunicable diseases. The Human Superorganism makes a sweeping, paradigm-shifting argument. It demolishes two fundamental beliefs that have blinkered all medical thinking until very recently: 1) Humans are better off as pure organisms free of foreign microbes; and 2) the human genome is the key to future medical advances. The microorganisms that we have sought to eliminate have been there for centuries supporting our ancestors. They comprise as much as 90 percent of the cells in and on our bodies-a staggering percentage! More than a thousand species of them live inside us, on our skin, and on our very eyelashes. Yet we have now significantly reduced their power and in doing so have sparked an epidemic of noncommunicable diseases-which now account for 63 percent of all human deaths. Ultimately, this book is not just about microbes; it is about a different way to view humans. The story that Dietert tells of where the new biology comes from, how it works, and the ways in which it affects your life is fascinating, authoritative, and revolutionary. Dietert identifies foods that best serve you, the superorganism; not new fad foods but ancient foods that have made sense for millennia. He explains protective measures against unsafe chemicals and drugs. He offers an empowering self-care guide and the blueprint for a revolution in public health. We are not what we have been taught. Each of us is a superorganism. The best path to a healthy life is through recognizing that profound truth.
Phd Rodney Dietert, Rodney Dietert, Rodney Dietert PhD, Rodney Dietert, Ph.D. (Author), Jonathan Todd Ross (Narrator)
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Natural Hospital Birth: The Best of Both Worlds
Natural Hospital Birth, Updated Edition shows how to apply the guidelines and tactics of natural birth in a hospital setting, where 99% of births take place. Many mothers-to-be find themselves torn between the desire for a natural childbirth with minimal medical intervention and the peace of mind offered by instant access to life-saving technology that only a hospital can provide. In Natural Hospital Birth, doula Cynthia Gabriel asserts that there is no good reason that women should not be able to have both. Cynthia shows expectant mothers what they can do to avoid unnecessary medical interventions and how to take initiative and consciously prepare for the kind of birth they want to have. Also included are inspiring stories from other women who know firsthand that natural birth in the hospital is possible. With this book, mothers-to-be will be equipped with the knowledge they need to ensure a satisfying hospital birth that they will look back on with peace and joy.
Cynthia Gabriel (Author), Norah Tocci (Narrator)
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This Idea is Brilliant: Lost, Overlooked, and Underappreciated Scientific Concepts Everyone Should K
The latest volume in the bestselling series from Edge.org-dubbed "the world's smartest website" by The Guardian-brings together 206 of the world's most innovative thinkers to discuss the scientific concepts that everyone should know. As science informs public policy, decision making, and so many aspects of our everyday lives, a scientifically literate society is crucial. In that spirit, Edge.org publisher and author of Know This, John Brockman, asks 206 of the world's most brilliant minds the 2017 Edge Question: What scientific term or concept ought to be more widely known? Contributors include: author of The God Delusion RICHARD DAWKINS on using animals' "Genetic Book of the Dead" to reconstruct ecological history; MacArthur Fellow REBECCA NEWBERGER GOLDSTEIN on "scientific realism," the idea that scientific theories explain phenomena beyond what we can see and touch; author of Seven Brief Lessons on Physics CARLO ROVELLI on "relative information," which governs the physical world around us; theoretical physicist LAWRENCE M. KRAUSS on the hidden blessings of "uncertainty"; cognitive scientist and author of The Language Instinct STEVEN PINKER on "The Second Law of Thermodynamics"; biogerontologist AUBREY DE GREY on why "maladaptive traits" have been conserved evolutionarily; musician BRIAN ENO on "confirmation bias" in the internet age; Man Booker-winning author of Atonement IAN MCEWAN on the "Navier-Stokes Equations," which govern everything from weather prediction to aircraft design and blood flow; plus pieces from RICHARD THALER, JARED DIAMOND, NICHOLAS CARR, JANNA LEVIN, LISA RANDALL, KEVIN KELLY, DANIEL COLEMAN, FRANK WILCZEK, RORY SUTHERLAND, NINA JABLONSKI, MARTIN REES, ALISON GOPNIK, and many, many others.
John Brockman (Author), Cassandra Campbell, Charles Constant (Narrator)
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The Drug Hunters: The Improbable Quest to Discover New Medicines
The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity-by chewing, brewing, and snorting-some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the five-thousand-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze-age medicine, a worm-killing birch fungus, knotted to his leggings. Nowadays, Big Pharma conglomerates spend billions of dollars on state-of-the art laboratories staffed by PhDs to discover blockbuster drugs. Yet, despite our best efforts to engineer cures, luck, trial-and-error, risk, and ingenuity are still fundamental to medical discovery. The Drug Hunters is a colorful, fact-filled narrative history of the search for new medicines from our Neolithic forebears to the professionals of today, and from quinine and aspirin to Viagra, Prozac, and Lipitor.
Donald R. Kirsch Ph.D., Donald R. Kirsch, Ph.D., Donald R. Kirsch, Phd, Ogi Ogas Ph.D., Ogi Ogas, Ph.D., Ogi Ogas, Phd, Ph.D. Kirsch, Ph.D. Ogas (Author), James Anderson Foster (Narrator)
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It All Adds Up: The Story of People and Mathematics
'Fascinating ... so enlightening that suddenly maths doesn't seem so fearsome as it once did' SIMON WINCHESTER From Aristotle to Ada Lovelace: a brief history of the mathematical ideas that have forever changed the world and the everyday people and pioneers behind them. The story of our best invention yet. From our ability to calculate the passing of time to the algorithms that control computers and much else in our lives, numbers are everywhere. They are so indispensable that we forget how fundamental they are to our way of life. In this international bestseller, Mickaël Launay mixes history and anecdotes from around the world to reveal how mathematics became pivotal to the story of humankind. It is a journey into numbers with Launay as a guide. In museums, monuments or train stations, he uses the objects around us to explain what art can reveal about geometry, how Babylonian scholars developed one of the first complex written languages, and how 'Arabic' numbers were adopted from India. It All Adds Up also tells the story of how mapping the trajectory of an eclipse has helped to trace the precise day of one of the oldest battles in history, how the course of the modern-day Greenwich Meridian was established, and why negative numbers were accepted just last century. This book is a vital compendium of the great men and women of mathematics from Aristotle to Ada Lovelace, which demonstrates how mathematics shaped the written word and the world. With clarity, passion and wisdom, the author unveils the unexpected and at times serendipitous ways in which big mathematical ideas were created. Supporting the belief that - just like music or literature - maths should be accessible to everyone, Launay will inspire a new fondness for the numbers that surround us and the rich stories they contain.
Mickael Launay (Author), Oli Hembrough, Oliver Hembrough (Narrator)
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The Social Leap: The New Evolutionary Science of Who We Are, Where We Come From, and What Makes Us H
In the compelling popular science tradition of Sapiens and Guns, Germs, and Steel, a groundbreaking and eye-opening exploration that applies evolutionary science to provide a new perspective on human psychology, revealing how major challenges from our past have shaped some of the most fundamental aspects of our being. The most fundamental aspects of our lives—from leadership and innovation to aggression and happiness—were permanently altered by the 'social leap' our ancestors made from the rainforest to the savannah. Their struggle to survive on the open grasslands required a shift from individualism to a new form of collectivism, which forever altered the way our mind works. It changed the way we fight and our proclivity to make peace, it changed the way we lead and the way we follow, it made us innovative but not inventive, it created a new kind of social intelligence, and it led to new sources of life satisfaction. In The Social Leap, William von Hippel lays out this revolutionary hypothesis, tracing human development through three critical evolutionary inflection points to explain how events in our distant past shape our lives today. From the mundane, such as why we exaggerate, to the surprising, such as why we believe our own lies and why fame and fortune are as likely to bring misery as happiness, the implications are far reaching and extraordinary. Blending anthropology, biology, history, and psychology with evolutionary science, The Social Leap is a fresh and provocative look at our species that provides new clues about who we are, what makes us happy, and how to use this knowledge to improve our lives.
William Von Hippel (Author), Michael David Axtell (Narrator)
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To Speak for the Trees: My Life's Journey from Ancient Celtic Wisdom to a Healing Vision of the Fore
Canadian botanist, biochemist and visionary Diana Beresford-Kroeger's startling insights into the hidden life of trees have already sparked a quiet revolution in how we understand our relationship to forests. Now, in a captivating account of how her life led her to these illuminating and crucial ideas, she shows us how forests can not only heal us but save the planet. When Diana Beresford-Kroeger--whose father was a member of the Anglo-Irish aristocracy and whose mother was an O'Donoghue, one of the stronghold families who carried on the ancient Celtic traditions--was orphaned as a child, she could have been sent to the Magdalene Laundries. Instead, the O'Donoghue elders, most of them scholars and freehold farmers in the Lisheens valley in County Cork, took her under their wing. Diana became the last ward under the Brehon Law. Over the course of three summers, she was taught the ways of the Celtic triad of mind, body and soul. This included the philosophy of healing, the laws of the trees, Brehon wisdom and the Ogham alphabet, all of it rooted in a vision of nature that saw trees and forests as fundamental to human survival and spirituality. Already a precociously gifted scholar, Diana found that her grounding in the ancient ways led her to fresh scientific concepts. Out of that huge and holistic vision have come the observations that put her at the forefront of her field: the discovery of mother trees at the heart of a forest; the fact that trees are a living library, have a chemical language and communicate in a quantum world; the major idea that trees heal living creatures through the aerosols they release and that they carry a great wealth of natural antibiotics and other healing substances; and, perhaps most significantly, that planting trees can actively regulate the atmosphere and the oceans, and even stabilize our climate. This book is not only the story of a remarkable scientist and her ideas, it harvests all of her powerful knowledge about why trees matter, and why trees are a viable, achievable solution to climate change. Diana eloquently shows us that if we can understand the intricate ways in which the health and welfare of every living creature is connected to the global forest, and strengthen those connections, we will still have time to mend the self-destructive ways that are leading to drastic fires, droughts and floods.
Diana Beresford-Kroeger (Author), Diana Beresford-Kroeger (Narrator)
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Tell Your Children: The Truth About Marijuana, Mental Illness, and Violence
An eye-opening report from an award-winning author and former New York Times reporter reveals the link between teenage marijuana use and mental illness, and a hidden epidemic of violence caused by the drug—facts the media have ignored as the United States rushes to legalize cannabis. Recreational marijuana is now legal in nine states. Almost all Americans believe the drug should be legal for medical use. Advocates argue cannabis can help everyone from veterans to cancer sufferers. But legalization has been built on myths– that marijuana arrests fill prisons; that most doctors want to use cannabis as medicine; that it can somehow stem the opiate epidemic; that it is not just harmless but beneficial for mental health. In this meticulously reported book, Alex Berenson, a former New York Timesreporter, explodes those myths: • Almost no one is in prison for marijuana; • A tiny fraction of doctors write most authorizations for medical marijuana, mostly for people who have already used; • Marijuana use is linked to opiate and cocaine use. Since 2008, the US and Canada have seen soaring marijuana use and an opiate epidemic. Britain has falling marijuana use and no epidemic; • Most of all, THC—the chemical in marijuana responsible for the drug's high—can cause psychotic episodes. After decades of studies, scientists no longer seriously debate if marijuana causes psychosis. Psychosis brings violence, and cannabis-linked violence is spreading. In the four states that first legalized, murders have risen 25 percent since legalization, even more than the recent national increase. In Uruguay, which allowed retail sales in July 2017, murders have soared this year. Berenson's reporting ranges from the London institute that is home to the scientists who helped prove the cannabis-psychosis link to the Colorado prison where a man now serves a thirty-year sentence after eating a THC-laced candy bar and killing his wife. He sticks to the facts, and they are devastating. With the US already gripped by one drug epidemic, this book will make readers reconsider if marijuana use is worth the risk.
Alex Berenson (Author), Alex Berenson (Narrator)
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Starry Messenger: Cosmic Perspectives on Civilisation
Bringing his cosmic perspective to civilization on Earth, Neil deGrasse Tyson, bestselling author of Astrophysics for People in a Hurry, shines new light on the crucial fault lines of our time–war, politics, religion, truth, beauty, gender, race, and tribalism–in a way that stimulates a deeper sense of unity for us all. In a time when our political and cultural perspectives feel more divisive than ever, Tyson provides a much-needed antidote to so much of what divides us, while making a passionate case for the twin engines of enlightenment–a cosmic perspective and the rationality of science. After thinking deeply about how a scientist views the world and about what Earth looks like from space, Tyson has found that terrestrial thoughts change as our brain resets and recalibrates life's priorities, along with the actions we might take in response. As a result, no outlook on culture, society, or civilisation remains untouched. In Starry Messenger, Tyson reveals just how human the enterprise of science is. Far from a cold, unfeeling undertaking, scientific methods, tools, and discoveries have shaped modern civilisation and created the landscape we've built for ourselves on which to live, work, and play. Tyson shows how an infusion of science and rational thinking renders worldviews deeper and more informed than ever before–and exposes unfounded perspectives and unjustified emotions. With crystalline prose and an abundance of evidence, Starry Messenger walks us through the scientific palette that sees and paints the world differently. From lessons on resolving global conflict to reminders of how precious it is to be alive, Tyson reveals, with warmth and eloquence, ten surprising, brilliant, and beautiful truths of human society, informed and enlightened by knowledge of our place in the universe.
Neil Degrasse Tyson (Author), Neil Degrasse Tyson (Narrator)
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Augmented: Life in The Smart Lane
The Internet and smartphone are just the latest in a 250-year-long cycle of disruption that has continuously changed the way we live, the way we work, and the way we interact. The coming Augmented Age, however, promises a level of disruption, behavioral shifts, and changes that are unparalleled. While consumers today are camping outside of an Apple store waiting to be one of the first to score a new Apple Watch or iPhone, the next generation of wearables will be able to predict if we're likely to have a heart attack and recommend a course of action. We watch news of Google's self-driving cars, but don't likely realize this means progressive cities will have to ban human drives in the next decade because us humans are too risky. Following on from the Industrial or Machine Age, the Space Age and the Digital Age, the Augmented Age will be based on four key disruptive themes-Artificial Intelligence, Experience Design, Smart Infrastructure, and HealthTech. Historically the previous "ages" bought significant disruption and changes, but on a net basis jobs were created, wealth was enhanced, and the health and security of society improved. What will the Augmented Age bring? Will robots take our jobs, and AI's subsume us as inferior intelligences, or will this usher in a new age of abundance? Augmented is a book on future history, but more than that, it is a story about how you will live your life in a world that will change more in the next twenty years than it has in the last 250 years. Are you ready to adapt? Because if history proves anything, you don't have much of a choice.
Alex Lightman, Andy Lark, Brett King, Jp Rangaswami (Author), Steven Jay Cohen (Narrator)
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Life on the Edge: The Coming of Age of Quantum Biology
Life is the most extraordinary phenomenon in the known universe; but how did it come to be? Even in an age of cloning and artificial biology, the remarkable truth remains: nobody has ever made anything living entirely out of dead material. Life remains the only way to make life. Are we still missing a vital ingredient in its creation? Jim Al-Khalili and Johnjoe Macfadden reveal the hitherto missing ingredient to be quantum mechanics and the strange phenomena that lie at the heart of this most mysterious of sciences. As they brilliantly demonstrate here, life lives on the quantum edge.
Jim Al-Khalili, Johnjoe McFadden, Johnjoe Mcfadden (Author), Pete Cross (Narrator)
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