This book presents pioneering findings on the characterization of cellular regulation and function for three recently identified protein posttranslational modifications (PTMs): lysine malonylation (Kmal), glutarylation (Kglu) and crotonylation (Kcr). It addresses three main topics: (i) Detecting Kmal substrates using a chemical reporter, which provides important information regarding the complex cellular networks modulated by Kmal; (ii) Identifying Kglu as a new histone PTM and assessing the direct impact of histone Kglu on chromatin structure and dynamics; and (iii) Revealing Sirt3's value as a regulating enzyme for histone Kcr dynamics and gene transcription, which opens new avenues for examining the physiological significance of histone Kcr. Taken together, these studies provide information critical to understanding how these protein PTMs are associated with various human diseases, and to identifying therapeutic targets for the dysregulation of these novel protein markers in varioushuman diseases.
| ISBN: | 9789811525117 |
| Publication date: | 21st March 2021 |
| Author: | Xiucong Bao |
| Publisher: | Springer an imprint of Springer Nature Singapore |
| Format: | Paperback |
| Pagination: | 163 pages |
| Series: | Springer Theses |
| Genres: |
Organic chemistry Genetics (non-medical) Biochemistry Cellular biology (cytology) Scientific equipment, experiments and techniques |
This book presents pioneering findings on the characterization of cellular regulation and function for three recently identified protein posttranslational modifications (PTMs): lysine malonylation (Kmal), glutarylation (Kglu) and crotonylation (Kcr). It addresses three main topics: (i) Detecting Kmal substrates using a chemical reporter, which provides important information regarding the complex cellular networks modulated by Kmal; (ii) Identifying Kglu as a new histone PTM and assessing the direct impact of histone Kglu on chromatin structure and dynamics; and (iii) Revealing Sirt3's value as a regulating enzyme for histone Kcr dynamics and gene transcription, which opens new avenues for examining the physiological significance of histone Kcr. Taken together, these studies provide information critical to understanding how these protein PTMs are associated with various human diseases, and to identifying therapeutic targets for the dysregulation of these novel protein markers in varioushuman diseases.
Study on the Cellular Regulation and Function of Lysine Malonylation, Glutarylation and Crotonylation features in the following genres: Organic chemistry, Genetics (non-medical), Biochemistry, Cellular biology (cytology), Scientific equipment, experiments and techniques
Study on the Cellular Regulation and Function of Lysine Malonylation, Glutarylation and Crotonylation is available in Paperback
Study on the Cellular Regulation and Function of Lysine Malonylation, Glutarylation and Crotonylation was written by Xiucong Bao and published by Springer an imprint of Springer Nature Singapore
Study on the Cellular Regulation and Function of Lysine Malonylation, Glutarylation and Crotonylation has 163 pages
Yes it is part of Springer Theses series
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