This thesis focuses on the development of gold- and non-classical platinum-based anti-cancer agents that display distinctively different anti-cancer mechanisms compared to the commonly used cisplatin. These metal complexes contain N-heterocyclic carbene (NHC) ligands which are able to form strong M-C(NHC) bonds, conferring high stability and favorable lipophilicity, reactivity and binding specificity of metal complexes on biomolecules. The author demonstrates significant advances made in anti-cancer gold(III), gold(I) and platinum(II) complexes. Detailed chemical synthesis, in vitro and/or in vivo anti-cancer activities are clearly presented including: (i) a class of Au(III) complexes containing a highly fluorescent N^N^N ligand and NHC ligand that simultaneously act as fluorescent thiol "switch-on" probes and anti-cancer agents; (ii) a dinuclear gold(I) complex with a mixed diphosphine and bis(NHC) ligand displaying favorable stability and showing significant inhibition of tumor growth in two independent mice models with no observable side effects; and (iii) a panel of stable luminescent cyclometalated platinum(II) complexes exhibiting high specificity to localize to the endoplasmic reticulum (ER) domain, inducing ER stress and cell apoptosis. These works highlight the clinical potential that gold and platinum complexes offer for cancer treatment.
| ISBN: | 9789811006562 |
| Publication date: | 2nd March 2016 |
| Author: | Taotao Zou |
| Publisher: | Springer an imprint of Springer Nature Singapore |
| Format: | Hardback |
| Pagination: | 164 pages |
| Series: | Springer Theses |
| Genres: |
Inorganic chemistry Medical research Oncology Medicinal chemistry |
This thesis focuses on the development of gold- and non-classical platinum-based anti-cancer agents that display distinctively different anti-cancer mechanisms compared to the commonly used cisplatin. These metal complexes contain N-heterocyclic carbene (NHC) ligands which are able to form strong M-C(NHC) bonds, conferring high stability and favorable lipophilicity, reactivity and binding specificity of metal complexes on biomolecules. The author demonstrates significant advances made in anti-cancer gold(III), gold(I) and platinum(II) complexes. Detailed chemical synthesis, in vitro and/or in vivo anti-cancer activities are clearly presented including: (i) a class of Au(III) complexes containing a highly fluorescent N^N^N ligand and NHC ligand that simultaneously act as fluorescent thiol "switch-on" probes and anti-cancer agents; (ii) a dinuclear gold(I) complex with a mixed diphosphine and bis(NHC) ligand displaying favorable stability and showing significant inhibition of tumor growth in two independent mice models with no observable side effects; and (iii) a panel of stable luminescent cyclometalated platinum(II) complexes exhibiting high specificity to localize to the endoplasmic reticulum (ER) domain, inducing ER stress and cell apoptosis. These works highlight the clinical potential that gold and platinum complexes offer for cancer treatment.
Anti-Cancer N-Heterocyclic Carbene Complexes of gold(III), gold(I) and platinum(III) features in the following genres: Inorganic chemistry, Medical research, Oncology, Medicinal chemistry
Anti-Cancer N-Heterocyclic Carbene Complexes of gold(III), gold(I) and platinum(III) is available in Hardback
Anti-Cancer N-Heterocyclic Carbene Complexes of gold(III), gold(I) and platinum(III) was written by Taotao Zou and published by Springer an imprint of Springer Nature Singapore
Anti-Cancer N-Heterocyclic Carbene Complexes of gold(III), gold(I) and platinum(III) has 164 pages
Yes it is part of Springer Theses series