With the aim of providing a deeper insight into possible mechanisms of biological self-organization, this thesis presents new approaches to describe the process of self-assembly and the impact of spatial organization on the function of membrane proteins, from a statistical physics point of view. It focuses on three important scenarios: the assembly of membrane proteins, the collective response of mechanosensitive channels and the function of the twin arginine translocation (Tat) system. Using methods from equilibrium and non-equilibrium statistical mechanics, general conclusions were drawn that demonstrate the importance of the protein-protein interactions. Namely, in the first part a general aggregation dynamics model is formulated, and used to show that fragmentation crucially affects the efficiency of the self-assembly process of proteins. In the second part, by mapping the membrane-mediated forces into a simplified many-body system, the dynamic and equilibrium behaviour of interacting mechanosensitive channels is derived, showing that protein agglomeration strongly impacts its desired function. The final part develops a model that incorporates both the agglomeration and transport function of the Tat system, thereby providing a comprehensive description of this self-organizing process.
| ISBN: | 9783642269943 |
| Publication date: | 29th November 2013 |
| Author: | Ksenia Guseva |
| Publisher: | Springer an imprint of Springer Berlin Heidelberg |
| Format: | Paperback |
| Pagination: | 80 pages |
| Series: | Springer Theses |
| Genres: |
Biophysics Cybernetics and systems theory Engineering applications of polymers and composites Mathematical physics Cellular biology (cytology) |
With the aim of providing a deeper insight into possible mechanisms of biological self-organization, this thesis presents new approaches to describe the process of self-assembly and the impact of spatial organization on the function of membrane proteins, from a statistical physics point of view. It focuses on three important scenarios: the assembly of membrane proteins, the collective response of mechanosensitive channels and the function of the twin arginine translocation (Tat) system. Using methods from equilibrium and non-equilibrium statistical mechanics, general conclusions were drawn that demonstrate the importance of the protein-protein interactions. Namely, in the first part a general aggregation dynamics model is formulated, and used to show that fragmentation crucially affects the efficiency of the self-assembly process of proteins. In the second part, by mapping the membrane-mediated forces into a simplified many-body system, the dynamic and equilibrium behaviour of interacting mechanosensitive channels is derived, showing that protein agglomeration strongly impacts its desired function. The final part develops a model that incorporates both the agglomeration and transport function of the Tat system, thereby providing a comprehensive description of this self-organizing process.
Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane features in the following genres: Biophysics, Cybernetics and systems theory, Engineering applications of polymers and composites, Mathematical physics, Cellular biology (cytology)
Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane is available in Paperback, Hardback
Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane was written by Ksenia Guseva and published by Springer an imprint of Springer Berlin Heidelberg
Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane has 80 pages
Yes it is part of Springer Theses series