In his thesis, Matthias Junk takes an innovative approach to assess the local structure and dynamics of biological and synthetic amphiphilic macromolecules capable of transporting small molecules. Replacing the latter with stable radicals, he uses state-of-the-art electron paramagnetic resonance (EPR) spectroscopy to describe the highly relevant transport function from the viewpoint of the guest molecules. Such, he demonstrates that the functional structure of human serum albumin in solution significantly differs from its crystal structure - a consequence of the protein's adaptability to host various endogenous compounds and drug molecules. Further, he shows that the thermal collapse of thermoresponsive hydrogels and dendronized polymers leads to static and dynamic heterogeneities on the nanoscale. These heterogeneities bear consequences for the material's hosting properties and enable unforeseen complex catalytic functionalities.
| ISBN: | 9783642251344 |
| Publication date: | 5th January 2012 |
| Author: | Matthias J N Junk |
| Publisher: | Springer an imprint of Springer Berlin Heidelberg |
| Format: | Hardback |
| Pagination: | 212 pages |
| Series: | Springer Theses |
| Genres: |
Engineering applications of polymers and composites Condensed matter physics (liquid state and solid state physics) Spectrum analysis, spectrochemistry, mass spectrometry Physical chemistry |
In his thesis, Matthias Junk takes an innovative approach to assess the local structure and dynamics of biological and synthetic amphiphilic macromolecules capable of transporting small molecules. Replacing the latter with stable radicals, he uses state-of-the-art electron paramagnetic resonance (EPR) spectroscopy to describe the highly relevant transport function from the viewpoint of the guest molecules. Such, he demonstrates that the functional structure of human serum albumin in solution significantly differs from its crystal structure - a consequence of the protein's adaptability to host various endogenous compounds and drug molecules. Further, he shows that the thermal collapse of thermoresponsive hydrogels and dendronized polymers leads to static and dynamic heterogeneities on the nanoscale. These heterogeneities bear consequences for the material's hosting properties and enable unforeseen complex catalytic functionalities.
Assessing the Functional Structure of Molecular Transporters by EPR Spectroscopy features in the following genres: Engineering applications of polymers and composites, Condensed matter physics (liquid state and solid state physics), Spectrum analysis, spectrochemistry, mass spectrometry, Physical chemistry
Assessing the Functional Structure of Molecular Transporters by EPR Spectroscopy is available in Hardback
Assessing the Functional Structure of Molecular Transporters by EPR Spectroscopy was written by Matthias J N Junk and published by Springer an imprint of Springer Berlin Heidelberg
Assessing the Functional Structure of Molecular Transporters by EPR Spectroscopy has 212 pages
Yes it is part of Springer Theses series