This thesis reports the latest developments in the direct amination of various C?H bonds using an H?Zn exchange/electrophilic amination strategy. McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines.
The material outlined in this book shows how McDonald achieved C?H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source.
McDonald's findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area.
| ISBN: | 9783319388779 |
| Publication date: | 26th August 2016 |
| Author: | Stacey L McDonald |
| Publisher: | Springer an imprint of Springer International Publishing |
| Format: | Hardback |
| Pagination: | 144 pages |
| Series: | Springer Theses |
| Genres: |
Organometallic chemistry Industrial chemistry and chemical engineering Medicinal chemistry |
This thesis reports the latest developments in the direct amination of various C?H bonds using an H?Zn exchange/electrophilic amination strategy. McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines.
The material outlined in this book shows how McDonald achieved C?H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source.
McDonald's findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area.
Copper-Catalyzed Electrophilic Amination of Sp2 and Sp3 C-H Bonds features in the following genres: Organometallic chemistry, Industrial chemistry and chemical engineering, Medicinal chemistry
Copper-Catalyzed Electrophilic Amination of Sp2 and Sp3 C-H Bonds is available in Hardback
Copper-Catalyzed Electrophilic Amination of Sp2 and Sp3 C-H Bonds was written by Stacey L McDonald and published by Springer an imprint of Springer International Publishing
Copper-Catalyzed Electrophilic Amination of Sp2 and Sp3 C-H Bonds has 144 pages
Yes it is part of Springer Theses series