In this acclaimed thesis, Eva Maria Huber reveals ground-breaking results by elucidating the crystal structure of the murine immunoproteasome in complex with a selective inhibitor. Huber does this by performing multidisciplinary methodologies including X-ray crystallography, fluorescence spectroscopy and mutagenesis experiments. Her exceptional results explore the immunoproteasome complex structures and are of outstanding importance for future scientific research especially in the pharmaceutical industry. These results will enable the functional analysis of individual proteasome subunits and support the development of novel drugs for autoimmune diseases such as multiple sclerosis or rheumatoid arthritis.
| ISBN: | 9783319378107 |
| Publication date: | 23rd August 2016 |
| Author: | Eva Maria Huber |
| Publisher: | Springer an imprint of Springer International Publishing |
| Format: | Paperback |
| Pagination: | 82 pages |
| Series: | Springer Theses |
| Genres: |
Analytical chemistry Biochemistry Medicinal chemistry |
In this acclaimed thesis, Eva Maria Huber reveals ground-breaking results by elucidating the crystal structure of the murine immunoproteasome in complex with a selective inhibitor. Huber does this by performing multidisciplinary methodologies including X-ray crystallography, fluorescence spectroscopy and mutagenesis experiments. Her exceptional results explore the immunoproteasome complex structures and are of outstanding importance for future scientific research especially in the pharmaceutical industry. These results will enable the functional analysis of individual proteasome subunits and support the development of novel drugs for autoimmune diseases such as multiple sclerosis or rheumatoid arthritis.
Structural and Functional Characterization of the Immunoproteasome features in the following genres: Analytical chemistry, Biochemistry, Medicinal chemistry
Structural and Functional Characterization of the Immunoproteasome is available in Paperback, Hardback
Structural and Functional Characterization of the Immunoproteasome was written by Eva Maria Huber and published by Springer an imprint of Springer International Publishing
Structural and Functional Characterization of the Immunoproteasome has 82 pages
Yes it is part of Springer Theses series