A key goal in the treatment of cancer is to achieve selective and efficient killing of tumor cells. The aim of Cell Death Signaling in Cancer Biology and Treatment is to describe state-of-the-art approaches and future opportunities for achieving this goal by targeting mechanisms and pathways that regulate cancer cell death. In this book, molecular defects in cell death signaling that characterize cancer cells, including dysregulation of cell death due to overexpression/hyperactivation of oncoproteins, as well as the loss of tumor suppressor proteins will be described. The potential for targeting microRNAs will be discussed. Multiple chapters will describe preclinical and clinical approaches that are currently being used to target epigenetic modifications, DNA repair pathways, and protein chaperones, as a means of provoking tumor cell death. Finally, the development and application of novel agents and approaches for targeting specific components of cell death signaling pathways and machinery will be reviewed.
| ISBN: | 9781493901074 |
| Publication date: | 13th December 2014 |
| Author: | Daniel Johnson |
| Publisher: | Humana Press an imprint of Springer New York |
| Format: | Paperback |
| Pagination: | 408 pages |
| Series: | Cell Death in Biology and Diseases |
| Genres: |
Cellular biology (cytology) Oncology |
A key goal in the treatment of cancer is to achieve selective and efficient killing of tumor cells. The aim of Cell Death Signaling in Cancer Biology and Treatment is to describe state-of-the-art approaches and future opportunities for achieving this goal by targeting mechanisms and pathways that regulate cancer cell death. In this book, molecular defects in cell death signaling that characterize cancer cells, including dysregulation of cell death due to overexpression/hyperactivation of oncoproteins, as well as the loss of tumor suppressor proteins will be described. The potential for targeting microRNAs will be discussed. Multiple chapters will describe preclinical and clinical approaches that are currently being used to target epigenetic modifications, DNA repair pathways, and protein chaperones, as a means of provoking tumor cell death. Finally, the development and application of novel agents and approaches for targeting specific components of cell death signaling pathways and machinery will be reviewed.
Cell Death Signaling in Cancer Biology and Treatment features in the following genres: Cellular biology (cytology), Oncology
Cell Death Signaling in Cancer Biology and Treatment is available in Paperback
Cell Death Signaling in Cancer Biology and Treatment was written by Daniel Johnson and published by Humana Press an imprint of Springer New York
Cell Death Signaling in Cancer Biology and Treatment has 408 pages
Yes it is part of Cell Death in Biology and Diseases series