The cell cycle is a sequence of biochemical events that are controlled by complex but robust molecular machinery. This enables cells to achieve accurate self-reproduction under a broad range of conditions. Environmental changes are transmitted by molecular signaling networks, which coordinate their actions with the cell cycle.
This work presents the first description of two complementary computational models describing the influence of osmotic stress on the entire cell cycle of S. cerevisiae. Our models condense a vast amount of experimental evidence on the interaction of the cell cycle network components with the osmotic stress pathway. Importantly, it is only by considering the entire cell cycle that we are able to make a series of novel predictions which emerge from the coupling between the molecular components of different cell cycle phases.
The model-based predictions are supported by experiments in S. cerevisiae and, moreover, have recently been observed in other eukaryotes. Furthermore our models reveal the mechanisms that emerge as a result of the interaction between the cell cycle and stress response networks.
| ISBN: | 9783319346205 |
| Publication date: | 23rd August 2016 |
| Author: | Elahe Radmaneshfar |
| Publisher: | Springer an imprint of Springer International Publishing |
| Format: | Paperback |
| Pagination: | 109 pages |
| Series: | Springer Theses |
| Genres: |
Biophysics Computational biology / bioinformatics Cellular biology (cytology) Combinatorics and graph theory Scientific equipment, experiments and techniques |
The cell cycle is a sequence of biochemical events that are controlled by complex but robust molecular machinery. This enables cells to achieve accurate self-reproduction under a broad range of conditions. Environmental changes are transmitted by molecular signaling networks, which coordinate their actions with the cell cycle.
This work presents the first description of two complementary computational models describing the influence of osmotic stress on the entire cell cycle of S. cerevisiae. Our models condense a vast amount of experimental evidence on the interaction of the cell cycle network components with the osmotic stress pathway. Importantly, it is only by considering the entire cell cycle that we are able to make a series of novel predictions which emerge from the coupling between the molecular components of different cell cycle phases.
The model-based predictions are supported by experiments in S. cerevisiae and, moreover, have recently been observed in other eukaryotes. Furthermore our models reveal the mechanisms that emerge as a result of the interaction between the cell cycle and stress response networks.
Mathematical Modelling of the Cell Cycle Stress Response features in the following genres: Biophysics, Computational biology / bioinformatics, Cellular biology (cytology), Combinatorics and graph theory, Scientific equipment, experiments and techniques
Mathematical Modelling of the Cell Cycle Stress Response is available in Paperback, Hardback
Mathematical Modelling of the Cell Cycle Stress Response was written by Elahe Radmaneshfar and published by Springer an imprint of Springer International Publishing
Mathematical Modelling of the Cell Cycle Stress Response has 109 pages
Yes it is part of Springer Theses series