This thesis describes the design, development, characterisation and clinical translation of three novel devices for optical endoscopic imaging. Over the past decade, rapid innovation in optics and photonics has led to the availability of low-cost and high-performance optical technologies that can be exploited for biomedical applications, but relatively few have been translated into clinic. The work presented outlines for the first time, a comprehensive analysis of the common barriers and unique challenges associated with the translation of optical imaging techniques. To assist developers streamline translation of optical imaging devices in future, a roadmap to clinical translation is outlined, and key translational characteristics are defined. Guided by these, subsequent development of endoscopic devices resulted in preparation and approval of endoscopes for first in human trials in the oesophagus, for early detection of cancer, and in the brain, for delineation of tumour during surgical resection. The thesis culminates in the presentation of results from the first in human use of a compact multispectral endoscope for imaging endogenous tissue contrast in the oesophagus. With continuation of the work as outlined at the end of this thesis, the novel techniques described have the potential to improve the standard of care in their respective indications.
| ISBN: | 9783030214838 |
| Publication date: | 14th August 2020 |
| Author: | Dale Jonathan Waterhouse |
| Publisher: | Springer Nature Switzerland AG |
| Format: | Paperback |
| Pagination: | 142 pages |
| Series: | Springer Theses |
| Genres: |
Medical imaging: radiology Nuclear chemistry, photochemistry and radiation Optical physics Applied optics Oncology |
This thesis describes the design, development, characterisation and clinical translation of three novel devices for optical endoscopic imaging. Over the past decade, rapid innovation in optics and photonics has led to the availability of low-cost and high-performance optical technologies that can be exploited for biomedical applications, but relatively few have been translated into clinic. The work presented outlines for the first time, a comprehensive analysis of the common barriers and unique challenges associated with the translation of optical imaging techniques. To assist developers streamline translation of optical imaging devices in future, a roadmap to clinical translation is outlined, and key translational characteristics are defined. Guided by these, subsequent development of endoscopic devices resulted in preparation and approval of endoscopes for first in human trials in the oesophagus, for early detection of cancer, and in the brain, for delineation of tumour during surgical resection. The thesis culminates in the presentation of results from the first in human use of a compact multispectral endoscope for imaging endogenous tissue contrast in the oesophagus. With continuation of the work as outlined at the end of this thesis, the novel techniques described have the potential to improve the standard of care in their respective indications.
Novel Optical Endoscopes for Early Cancer Diagnosis and Therapy features in the following genres: Medical imaging: radiology, Nuclear chemistry, photochemistry and radiation, Optical physics, Applied optics, Oncology
Novel Optical Endoscopes for Early Cancer Diagnosis and Therapy is available in Paperback, Hardback
Novel Optical Endoscopes for Early Cancer Diagnosis and Therapy was written by Dale Jonathan Waterhouse and published by Springer Nature Switzerland AG
Novel Optical Endoscopes for Early Cancer Diagnosis and Therapy has 142 pages
Yes it is part of Springer Theses series
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