It is evident that a defective or deregulated complement system results in kidney diseases. An important role of complement effector and regulatory proteins in pathological settings of the kidney has been demonstrated. A large panel of distinct human kidney diseases is caused by defective complement control. Genetic analyses have identified mutations in complement regulators that are associated with these diseases. Mutations have been identified in the fluid phase alternative pathway regulator Factor H and the membrane regulator Membrane Cofactor Protein MCP (CD46). The functional characterization of the mutant proteins allows to define the pathophysiological events on a molecular level. These new concepts and data on disease mechanisms allowed establishing new diagnostic and promising therapeutic approaches for several human kidney diseases. Molecular biology, clinics and therapy are discussed in this volume.
| ISBN: | 9783764371661 |
| Publication date: | 9th December 2005 |
| Author: | Peter F Zipfel |
| Publisher: | Birkhauser an imprint of Birkhäuser Basel |
| Format: | Hardback |
| Pagination: | 236 pages |
| Series: | Progress in Inflammation Research |
| Genres: |
Immunology Medical microbiology and virology Cellular biology (cytology) Renal medicine and nephrology Physiology Clinical and internal medicine |
It is evident that a defective or deregulated complement system results in kidney diseases. An important role of complement effector and regulatory proteins in pathological settings of the kidney has been demonstrated.
Complement and Kidney Disease features in the following genres: Immunology, Medical microbiology and virology, Cellular biology (cytology), Renal medicine and nephrology, Physiology, Clinical and internal medicine
Hardback. Not Available.
Complement and Kidney Disease was written by Peter F Zipfel and published by Birkhauser an imprint of Birkhäuser Basel
Complement and Kidney Disease has 236 pages
Yes it is part of Progress in Inflammation Research series