This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker - the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.
| ISBN: | 9783642436529 |
| Publication date: | 9th August 2014 |
| Author: | Thomas E Ouldridge |
| Publisher: | Springer an imprint of Springer Berlin Heidelberg |
| Format: | Paperback |
| Pagination: | 176 pages |
| Series: | Springer Theses |
| Genres: |
Biophysics Cybernetics and systems theory Condensed matter physics (liquid state and solid state physics) Engineering applications of polymers and composites Mathematical physics Nanotechnology |