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Siddhartha Mukherjee M.D., Ph.D., is a cancer physician and researcher. He is an assistant professor of medicine at Columbia University and a cancer physician at the CU/NYU Presbyterian Hospital. A Rhodes Scholar, he graduated from Stanford University, University of Oxford, and from Harvard Medical School and was a Fellow at the Dana Farber Cancer Institute and an attending physician at the Massachusetts General Hospital and Harvard Medical School. He has published articles in Nature, New England Journal of Medicine, Neuron, the Journal of Clinical Investigation, The New York Times, and The New Republic. He lives in New York with his wife and daughter.
Author photo © Deborah Feingold
Spanning the globe and several centuries, The Gene is the story of the quest to decipher the master-code that makes and defines humans, that governs our form and function. The story of the gene begins in an obscure Augustinian abbey in Moravia in 1856 where a monk stumbles on the idea of a 'unit of heredity'. It intersects with Darwin's theory of evolution, and collides with the horrors of Nazi eugenics in the 1940s. The gene transforms post-war biology. It reorganizes our understanding of sexuality, temperament, choice and free will. This is a story driven by human ingenuity and obsessive minds - from Charles Darwin and Gregor Mendel to Francis Crick, James Watson and Rosalind Franklin, and the thousands of scientists still working to understand the code of codes. This is an epic, moving history of a scientific idea coming to life, by the author of The Emperor of All Maladies. But woven through The Gene, like a red line, is also an intimate history - the story of Mukherjee's own family and its recurring pattern of mental illness, reminding us that genetics is vitally relevant to everyday lives. These concerns reverberate even more urgently today as we learn to read and write the human genome - unleashing the potential to change the fates and identities of our children.
Winner of the Guardian First Book Award 2011. Shortlisted for the Wellcome Trust Book Prize 2011. Winner of the Pulitzer Prize for General Non-Fiction 2011. A magnificent, beautifully written biography of cancer -- from its first documented appearances thousands of years ago through the epic battles to cure, control and conquer it, to a radical new understanding of its essence. Author and academic Sarah Churchwell, who was on the judging panel, said: “The Emperor of All Maladies is a cultural history of cancer and its treatment, from its first identification as a disease in the ancient world to 21st century research into its cellular genesis and treatment. “Siddhartha Mukherjee has marshalled an immense amount of material into a readable and inspiring story. The result is a gripping, enlightening read about the nature of illness and our battle against what begins to look like mortality itself.”
Groartig, fesselnd und folgenreich: Pulitzer-Preistrager Siddhartha Mukherjee erzahlt meisterhaft die Geschichte der Entzifferung des Mastercodes, der unser Menschsein bestimmt. Als Siddhartha Mukherjee seinen Bestseller Der Konig aller Krankheiten beendet hatte, machte er sich auf eine Reise in die indische Heimat. Er besucht Cousin Moni, der an Schizophrenie leidet - wie auffallig viele seiner Verwandten. Fasziniert beginnt Mukherjee sich mit der Geschichte der Gene zu beschaftigen: Von den Erbsenkreuzungen Mendels bis zur neuesten Gen-Bearbeitungs-Methode CRISPR schreibt Mukherjee den spannenden Roman einer wissenschaftlichen Suche und verwebt ihn mit der Geschichte seiner Familie. Das groe Buch eines begnadeten Erzahlers und Arztes, das gewaltige Panorama einer machtvollen Entdeckung, die man nun endlich versteht. Packend und einzigartig."e;Wer wissen will, was es bedeutet, Mensch zu sein, sollte dieses Buch lesen."e; Boston Globe"e;Lesen Sie dieses Buch, so werden Sie auf die Zukunft bestens vorbereitet sein. "e; Sunday Times "e;Meisterhaft aufgebaut, wunderbar erzahlt [...] Mukherjee ist ein Genie darin, zutiefst menschliche Geschichten hinter abstrakten Ideen zu entdecken."e; Andrew Solomon, Washington Post "e;Eine inspirierende und ungemein bewegende Lekture."e; San Francisco Chronicle
** NEW YORK TIMES NUMBER ONE BESTSELLER ** The Gene is the story of one of the most powerful and dangerous ideas in our history from the author of The Emperor of All Maladies. The story begins in an Augustinian abbey in 1856, and takes the reader from Darwin's groundbreaking theory of evolution, to the horrors of Nazi eugenics, to present day and beyond - as we learn to read and write the human genome that unleashes the potential to change the fates and identities of our children. Majestic in its scope and ambition, The Gene provides us with a definitive account of the epic history of the quest to decipher the master-code that makes and defines humans - and paints a fascinating vision of both humanity's past and future. For fans of Sapiens by Yuval Noah Harari, A Brief History of Time by Stephen Hawking and Being Mortal by Atul Gwande. 'Siddhartha Mukherjee is the perfect person to guide us through the past, present, and future of genome science' Bill Gates 'A thrilling and comprehensive account of what seems certain to be the most radical, controversial and, to borrow from the subtitle, intimate science of our time...Read this book and steel yourself for what comes next' Sunday Times
Siddhartha Mukherjee, Pulitzer-Preistrager und Autor des Bestsellers Der Konig aller Krankheiten: Krebs - eine Biographie fragt sich in seinem TED Book, welchen Gesetzen die Medizin gehorcht. Diese Frage begleitete den Arzt Siddhartha Mukherjee uber viele Jahre und mit der Zeit konnte er die wesentlichen Prinzipien der Medizin ausmachen und benennen. Dabei geht es beispielsweise um die wichtige Rolle der Intuition beim Erstellen von Diagnosen. Reich an faszinierenden historischen Details und Erfahrungen aus der modernen Medizin ermoglicht Mukherjees Buch uns ein ganz neues Verstandnis von Medizin. Ein wichtiges Buch fur Arzte und Patienten.
From the Pulitzer Prize-winning, bestselling author of The Emperor of All Maladiesa magnificent history of the gene and a response to the defining question of the future: What becomes of being human when we learn to read and write our own genetic information?The extraordinary Siddhartha Mukherjee has a written a biography of the gene as deft, brilliant, and illuminating as his extraordinarily successful biography of cancer. Weaving science, social history, and personal narrative to tell us the story of one of the most important conceptual breakthroughs of modern times, Mukherjee animates the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices. Throughout the narrative, the story of Mukherjees own familywith its tragic and bewildering history of mental illnesscuts like a bright, red line, reminding us of the many questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In superb prose and with an instinct for the dramatic scene, he describes the centuries of research and experimentationfrom Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Thomas Morgan to Crick, Watson and Rosa Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome. As The New Yorker said of The Emperor of All Maladies, Its hard to think of many books for a general audience that have rendered any area of modern science and technology with such intelligence, accessibility, and compassionAn extraordinary achievement. Riveting, revelatory, and magisterial history of a scientific idea coming to life, and an essential preparation for the moral complexity introduced by our ability to create or write the human genome, The Gene is a must-read for everyone concerned about the definition and future of humanity. This is the most crucial science of our time, intimately explained by a master.
Spanning the globe and several centuries, The Gene is the story of the quest to decipher the master-code that makes and defines humans, that governs our form and function. The story of the gene begins in an obscure Augustinian abbey in Moravia in 1856, where a monk stumbles on the idea of a unit of heredity . It intersects with Darwin s theory of evolution, and collides with the horrors of Nazi eugenics in the 1940s. The gene transforms post-war biology. It reorganizes our understanding of sexuality, temperament, choice and free will. Above all, this is a story driven by human ingenuity and obsessive minds from Charles Darwin and Gregor Mendel to Francis Crick, James Watson and Rosalind Franklin, and the thousands of scientists still working to understand the code of codes. This is an epic, moving history of a scientific idea being brought to life, by the author of The Emperor of All Maladies. But woven through The Gene, like a red line, is also an intimate history the story of Mukherjee s own family and its recurring pattern of mental illness, reminding us that genetics is vitally relevant to everyday lives. These concerns reverberate even more urgently today as we learn to read and write the human genome unleashing the potential to change the fates and identities of our children. Majestic in its ambition, and unflinching in its honesty, The Gene gives us a definitive account of the fundamental unit of heredity and a vision of both humanity s past and future.
A Simon & Schuster audiobook. Simon & Schuster has a great book for every listener.
Essential, required listening for doctors and patients alike: A Pulitzer Prize-winning author and one of the worlds premiere cancer researchers reveals an urgent philosophy on the little-known principles that govern medicineand how understanding these principles can empower us all.Over a decade ago, when Siddhartha Mukherjee was a young, exhausted, and isolated medical resident, he discovered a book that would forever change the way he understood the medical profession. The book, The Youngest Science, forced Dr. Mukherjee to ask himself an urgent, fundamental question: Is medicine a science? Sciences must have lawsstatements of truth based on repeated experiments that describe some universal attribute of nature. But does medicine have laws like other sciences? Dr. Mukherjee has spent his career pondering this questiona question that would ultimately produce some of most serious thinking he would do around the tenets of his disciplineculminating in The Laws of Medicine. In this important treatise, he investigates the most perplexing and illuminating cases of his career that ultimately led him to identify the three key principles that govern medicine. Brimming with fascinating historical details and modern medical wonders, this important book is a fascinating glimpse into the struggles and Eureka! moments that people outside of the medical profession rarely see. Written with Dr. Mukherjees signature eloquence and passionate prose, The Laws of Medicine is a critical book, not just for those in the medical profession, but for everyone who is moved to better understand how their health and well-being is being treated. Ultimately, this book lays the groundwork for a new way of understanding medicine, now and into the future.
The Laws of Medicine follows Pulitzer-Prize-winning author, Dr Mukherjee as he investigates some of the most perplexing and illuminating cases of his career - the cases that ultimately led him to identify the three key principles that govern medicine. As a young medical student, Mukherjee discovered The Youngest Science, a book that changed the way he understood the medical profession and forced him to ask himself an urgent, fundamental question: Is medicine a 'science'? Science must have laws - statements of truth based on repeated experiments that describe some universal attribute of nature. Dr Mukherjee has spent his career pondering whether the 'youngest science' has laws like the other sciences, culminating in this treatise The Laws of Medicine. Law 1: Rumours are more important than tests. Law 2: The piece of data that does not fit your model is the most crucial piece of data that you own. Law 3: For every perfect medical experiment, there is a perfect human bias. Brimming with fascinating historical details and modern medical wonders, this book is a glimpse into the struggles and Eureka! moments rarely seen by those outside the profession.
A comprehensive history of cancer - one of the greatest enemies of medical progress - and an insight into its effects and potential cures, by a leading expert on the illness. In The Emperor of All Maladies, Siddhartha Mukherjee, doctor, researcher and award-winning science writer, examines cancer with a cellular biologist's precision, a historian's perspective, and a biographer's passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with - and perished from - for more than five thousand years. The story of cancer is a story of human ingenuity, resilience and perseverance, but also of hubris, arrogance and misperception, all leveraged against a disease that, just three decades ago, was thought to be easily vanquished in an all-out 'war against cancer'. Mukherjee recounts centuries of discoveries, setbacks, victories and deaths, told through the eyes of predecessors and peers, training their wits against an infinitely resourceful adversary. From the Persian Queen Atossa, whose Greek slave cut off her malignant breast, to the nineteeth-century recipient of primitive radiation and chemotherapy and Mukherjee's own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through toxic, bruising, and draining regimes to survive and to increase the store of human knowledge. Riveting and magesterial, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments and a brilliant new perspective on the way doctors, scientists, philosophers and lay people have observed and understood the human body for millennia.