Join journalist Barry Werth as he pulls back the curtain on Vertex, a start-up pharmaceutical company, and witness firsthand the intense drama being played out in the pioneering and hugely profitable field of drug research.
Founded by Joshua Boger, a dynamic Harvard- and Merck-trained scientific whiz kid, Vertex is dedicated to designing-atom by atom-both a new life-saving immunosuppressant drug, and a drug to combat the virus that causes AIDS.
You will be hooked from start to finish, as you go from the labs, where obsessive, fiercely competitive scientists struggle for a breakthrough, to Wall Street, where the wheeling and dealing takes on a life of its own, as Boger courts investors and finally decides to take Vertex public. Here is a fascinating no-holds-barred account of the business of science, which includes an updated epilogue about the most recent developments in the quest for a drug to cure AIDS.
In The Antidote, journalist Barry Werth draws upon unprecedented inside reporting spanning more than two decades to provide a groundbreaking closeup of the upstart pharmaceutical company Vertex and the ferocious but indispensable world of Big Pharma that it inhabits.
In 1989, the charismatic Joshua Boger left Merck, then America’s most admired business, to found a drug company that would challenge industry giants and transform health care. Barry Werth described the company's tumultuous early days during the AIDS crisis in The Billion-Dollar Molecule, a celebrated classic of science and business journalism. Now he returns to tell a riveting story of Vertex's bold endurance and eventual success.
The $325-billion-a-year pharmaceutical business is America's toughest and one of its most profitable. It is riskier and more rigorous at just about every stage than any other business, from the towering biological uncertainties inherent in its mission to treat disease; to the 30-to-1 failure rate in bringing out a successful medicine even after a molecule clears all the hurdles to get to human testing; to the multibillion-dollar cost of ramping up a successful product; to operating in the world's most regulated industry, matched only by nuclear power.
Werth captures the full scope of Vertex's twenty-five-year drive to deliver breakthrough medicines. At a time when America struggles to maintain its innovative edge, The Antidote is a powerful inside look at one of the most intriguing and important business stories of recent decades.
In 31 Days, Barry Werth takes readers inside the White House during the tumultuous days following Nixon's resignation and the swearing-in of America's "accidental president," Gerald Ford. The congressional hearings, Nixon's increasing paranoia, and, finally, the devastating revelations of the White House tapes had torn the country apart. Within the White House and the Republican Party, Nixon's resignation produced new fissures and battle lines-and new opportunities for political advancement.
Ford had to reassure the nation and the world that he would attend to the pressing issues of the day, from resolving the legal questions surrounding Nixon's role in Watergate, to dealing with the wind down of the Vietnam War, the precarious state of détente with the Soviet Union, and the ongoing attempts to stabilize the Middle East. Within hours of Nixon's departure from Washington, Ford began the all-important task of forming an inner circle of trusted advisers.
In richly detailed scenes, Werth describes the often vicious sparring among two mutually distrustful staffs-Nixon's and Ford's vice presidential holdovers-and a transition team that included Donald Rumsfeld (then Nixon's ambassador to NATO) and Rumsfeld's former deputy, the thirty-three-year-old coolly efficient Richard Cheney. The first detailed account of the ruthless maneuvering and day-to-day politicking behind everything from the pardon of Nixon to why George H. W. Bush was passed over for the vice presidency, to the rise of a new cadre of Republican movers and shakers, 31 Days offers a compelling perspective on a fascinating but relatively unexamined period in American history and its impact on the present.
