Metabolic Networks, Elementary Flux Modes, and Polyhedral Cones

Metabolic Networks, Elementary Flux Modes, and Polyhedral Cones Synopsis

Expositions of quantitative methods and algorithms for biological data tend to be scattered through the technical literature, often across different fields, and are thus awkward to assimilate. This book documents one example of this: the relationship between the cell biology idea of metabolic networks and the mathematical idea of polyhedral cones. Such cones can be used to describe the set of steady-state admissible fluxes through metabolic networks, and consequently have become important constructs in the field of microbiology.

Via convex cone concepts, fundamental objects called elementary flux modes (EFMs) can be described mathematically. The fundamental algorithm of this relationship is the double description method, which has an extended history in the field of computational geometry. This monograph addresses its relatively recent use in the context of cellular metabolism.

Metabolic Networks, Elementary Flux Modes, and Polyhedral Cones:

• Addresses important topics in the mathematical description of metabolic activity that have not previously appeared in unified form.
• Introduces a central topic of mathematical systems biology in a manner accessible to nonmathematicians with some mathematical and computational experience.
• Presents a careful study of the double description method, a fundamental algorithm of computational geometry, in the context of metabolic analysis.