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Biochemistry

See below for a selection of the latest books from Biochemistry category. Presented with a red border are the Biochemistry books that have been lovingly read and reviewed by the experts at Lovereading. With expert reading recommendations made by people with a passion for books and some unique features Lovereading will help you find great Biochemistry books and those from many more genres to read that will keep you inspired and entertained. And it's all free!

Hydroxyl Radicals Properties, Functions and Impact

Hydroxyl Radicals Properties, Functions and Impact

Author: Sidney Pierce Format: Paperback / softback Release Date: 09/03/2020

To understand the reaction of OH in detail at the surface of a photocatalyst, an electrochemical analysis of the irradiated semiconductors was attempted via the fluorescence probe method. For the single crystal rutile TiO2 electrodes, the facet dependence on the OH formation could be observed along with oxygen evolution by the photooxidation of water. In the subsequent study, the authors present the kinetics and mechanism of the gas-phase reaction of CH3CH2OCH2CH2Cl (2-chloroethyl ethyl ether, 2ClEEE) with OH radical using quantum chemical methods. Optimization and frequency calculations of all the species involved in the reactions were carried out at BHandHLYP/6-311++G(2d,2p) level of theory. The closing chapter is focused on the effect of hydroxyl radical and the regulation mechanism. Host immune systems generate reactive oxygen species) in order to defend microbial pathogens. Reactive oxygen species induce oxidative stress and encompass nonradical oxidants, such as hydrogen peroxide and singlet oxygen, as well as oxygen free radicals, such as superoxide anion radical and hydroxyl radical.

Micronucleus Assay: An Overview

Micronucleus Assay: An Overview

Author: Robert C. Cole Format: Paperback / softback Release Date: 02/03/2020

Micronucleus is defined as the small nucleus that forms whenever a chromosome or its fragment is not incorporated into one of the daughter nuclei during cell division. It is concluded that micronucleus assay can be used for risk prediction, screening, diagnosis and treatment of various chronic diseases. In this Micronucleus Assay: An Overview, the applications of micronucleus assay will be discussed. Ionizating radiations, ultraviolet rays, geogenic or anthropogenic pollutants can induce mutagenic, teratogenic or carcinogenic effects due to the induction of micro or macrolession over DNA. Several models have been used to measure the mutagenic and clastogenic effect of such agents. As such, the authors focus on one of these models: the micronucleus test. The micronucleus test can assess abnormalities earlier in the drug discovery pipeline, making structure/genotoxicity connection a possible system for drug characterization. Additionally, the authors provide knowledge about micronucleus assay and its usage in occupational toxicology studies. It is now recognized as one of the most successful and reliable assays for genotoxic carcinogens. The authors go on to present an overview of the evaluation of micronucleus assay by flow cytometry, reviewing the studies published in the international literature so far that employ different experimental designs for a variety of purposes. Humans can become exposed to a variety of chemical substances that can have adverse biological effects, and the sub-lethal genotoxicity can have the most far reaching and severe consequences like cancer or abnormal progeny as per the cell type involved. Hence, the penultimate chapter focuses on the significance of identifying and predicting potential genotoxic agents by using laboratory markers, thus regulating and preventing exposure to cancer causing agents In the concluding review, generation of micronucleus assay in the bone marrow cells of mice induced by various clastogenic chemicals, drugs, and radiation are elaborately elucidated. Bone marrow cells are easily susceptible to oxidative damage and sensitive to various clastogenic as well as aneugenic agents.

The Essential Guide to Vitamin D

The Essential Guide to Vitamin D

Author: Jana Andelova Format: Paperback / softback Release Date: 26/02/2020

The guide first discusses vitamin D receptor, a member of the superfamily of nuclear steroid/thyroid hormone receptors that can be found in both the cytoplasm and nucleus. It acts mainly as a ligand-dependent DNA-binding transcriptional factor mediating the actions of the biological active form of vitamin D (VD), the metabolite 1I+/-,25[OH]2D3. Vitamin D has a complex role in the human body. Beside the classical effects in bone mineralization, a significant amount of data regarding the role of this vitamin in cell differentiation, defense mechanism, allergy, inflammation, metabolism and hormonal regulation continue to accumulate. As such, the relevance of these effects for lung disorders is under investigation. Vitamin D is a hormone with pleiotropic effects; it controls calcium homeostasis, immune response, and hemodynamic wall stress. In the last decade, numerous studies have focused on the role of vitamin D levels in cardiovascular disease. In particular, it has been shown that insufficient Vitamin D levels are frequently observed among patients with cardiovascular disease. Additionally, calcitriol, which is also called 1, 25-dihydroxy vitamin D3, is involved in several physiological processes maintaining balanced bone turnover and a healthy bone microenvironment. The beneficial effects of vitamin D on bone biomechanical features are not exclusively attributable to the reduction in non-mineralized bone matrix, but to the osteocyte number and their connectivity, too. Studies have reported that Vitamin D is essential for recovery of hospitalized patients as they are at increased risk of developing/worsening vitamin D deficiency due to lack of availability of sources of the vitamin. Various cognitive disorders have also been associated with hypovitaminosis D. Vitamin D has also been proposed as a risk-modifying factor for many chronic diseases, including multiple sclerosis, schizophrenia, cognitive issues, hypertension, heart disease, diabetes, cancer, psoriasis, and other autoimmune diseases. Vitamin D deficiency is the main cause of osteoporosis and osteomalacia in adults and rickets in children. The low serum of this vitamin is common in patients suffering from cardiovascular, autoimmune, cancer, psoriasis, depression and atherosclerosis disorder. The highly sensitive nature of vitamin D to environmental factors including light, heat, and oxygen, as well as hydrophobicity and acid labile nature, are the major drawbacks that need to be addressed for development of an efficient formulation for vitamin D.

Jak-STAT Signaling in Diseases

Jak-STAT Signaling in Diseases

Author: Ritobrata Goswami Format: Hardback Release Date: 24/02/2020

JAK-STAT pathway is one of the few signal transduction pathways that transduce signals involved in multiple homeostatic biological processes including cell differentiation and proliferation, cell death, hematopoiesis and immune responses. JAK-STAT is an elegant pathway that is relatively simple and evolutionary conserved as gene expression is regulated by external parameters. Activated by growth factors or cytokines, this signal transduction cascade regulates the transcription of genes at the nucleus. Mutations and polymorphisms in JAK-STAT pathway are associated with inflammatory diseases and cancers that could impede regular homeostasis. Features: Details activation and microRNA-mediated regulation of JAK-STAT pathway Provides exclusive information about the association of the pathway in various diseases including allergic inflammation, neuro-inflammatory disorder, atopic dermatitis hematopoietic malignancies, cardiovascular disorder, renal disorder, immunodeficiency, liver fibrosis, diabetes and obesity that affect individuals across the globe Clinical relevance of the signaling cascade has been discussed in context of novel class of therapeutics that targets this pathway. An overview of JAK-STAT signaling pathway and the structure-function relationship of different domains of the cascade are discussed. This book provides detailed information on various diseases that are associated with JAK-STAT pathway. It will act as a very good reference book for basic science researchers, academicians, industry professionals involved in translational research leading to product development. This book will excite future professionals towards better understanding of the regulation of this pathway, its association with other signaling cascades to design novel therapeutics.

Lignin Chemistry

Lignin Chemistry

Author: Luis Serrano Format: Hardback Release Date: 21/02/2020

The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.

Chemical and Synthetic Biology Approaches to Understand Cellular Functions - Part C

Chemical and Synthetic Biology Approaches to Understand Cellular Functions - Part C

Author: Arun K. (Indian Institute of Technology, Kanpur, India) Shukla Format: Hardback Release Date: 15/02/2020

Chemical and Synthetic Biology Approaches to Understand Cellular Functions - Part C, Volume 633, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial. This release includes sections on Next generation probes for molecular imaging in cells, Competitive binding assay for biotin and biotin derivatives, based on avidin and biotin-4-fluorescein, Converting avidin to bind ligands other than biotin, especially steroids, Chemoenzymatic Labeling Strategy, Engineered Siderophores, Small molecules to inhibit bacterial population behavior, NMR tube bioreactor, Small molecule controlled RAS activation system, Small molecule regulated Cas9, the Design and application of synthetic receptors, and much more.

Vitamin C Biochemistry and Function

Vitamin C Biochemistry and Function

Author: Qi (University of Kansas Medical Center, Kansas City, Kansas, USA) Chen Format: Hardback Release Date: 06/02/2020

Vitamin C holds a unique place in scientific and cultural history. In this book, a group of leading scientific research explore the myriad ways Vitamin C is employed during normal physiological function. This book also provides updates on recent uses ofVitamin C in cancer treatment through high dose intravenous therapies, the ways Vitamin C reduces or prevents sepsis and in the treatment of infectious disease, and the ways Vitamin C improves succesful stem cell transplantation, as well as other health implications. Key selling features: Reviews the history and recent research on the benefits and uses of Vitamin C Focuses special attention on the ways Vitamin C can be used in the treatment of cancers Discusses how Vitamin C is employed against infectious disease Includes chapters from a team of leading international scholars

Priming-Mediated Stress and Cross-Stress Tolerance in Crop Plants

Priming-Mediated Stress and Cross-Stress Tolerance in Crop Plants

Priming-Mediated Stress and Cross-Stress Tolerance in Crop Plants is the first comprehensive overview of the latest understanding of the physiological, biochemical and molecular basis of priming mediated stress tolerance and cross-stress tolerance in plants. Plants have developed unique strategies to respond to ever-changing environmental conditions, which enables them to monitor their surroundings and adjust their metabolic systems to maintain homeostasis. Key components involved in plant stress interactions are discussed in this book, including stress stimulus, signal transduction, transcription regulators, target genes, and stress responses. These topics have recently attracted considerable interest within the scientific community, as a potential means of stress management and in the production of stress-resistant crops that aid in global food security. Since many studies dealing with a range of plant species, under different conditions, have focused on priming mediated stress and cross-stress tolerance in plants, with recent results indicating that plants have a memory process where a past stress exposure enables them to be better prepared for exposure to stress in the future, this book is an ideal reference on the topic.

Aquaporin Regulation

Aquaporin Regulation

Author: Litwack Format: Hardback Release Date: 01/02/2020

Aquaporin Regulation, Volume 112, the latest release in the Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting interesting chapters highlighting Perspectives on the evolution of aquaporin superfamily, Structure and dynamics of aquaporin-1, Selectivity and Transport in Aquaporins from Molecular Simulation Studies, Aquaporin regulation in metabolic organs, Phosphorylation of human AQP2 and its role in trafficking, Regulation of Aquaporin-2 by RNA Interference, Aquaporin Regulation: Lessons from Secretory Vesicles, CFTR Regulation of Aquaporin-mediated Water Transport, Glucocorticoid Gene Regulation of Aquaporin-7, and much more.

Tumor Immunology and Immunotherapy - Cellular Methods Part B

Tumor Immunology and Immunotherapy - Cellular Methods Part B

Author: Lorenzo (Weill Cornell Medical College, USA) Galluzzi Format: Hardback Release Date: 01/02/2020

Tumor Immunology and Immunotherapy - Cellular Methods Part B, Volume 632, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Topics covered include Quantitation of calreticulin exposure associated with immunogenic cell death, Side-by-side comparisons of flow cytometry and immunohistochemistry for detection of calreticulin exposure in the course of immunogenic cell death, Quantitative determination of phagocytosis by bone marrow-derived dendritic cells via imaging flow cytometry, Cytofluorometric assessment of dendritic cell-mediated uptake of cancer cell apoptotic bodies, Methods to assess DC-dependent priming of T cell responses by dying cells, and more.

Trends in Biochemistry and Molecular Biology

Trends in Biochemistry and Molecular Biology

Author: Hossain Uddin Shekhar Format: Paperback / softback Release Date: 29/01/2020

This book provides the essential information necessary for students in the life and health sciences. The book adopts a readable, student-friendly style that helps introduce students to this fascinating and often-times daunting subject. Each chapter begins with a summary of essential facts followed by descriptions of the subjects that focus on core information with clear, simple diagrams that are easy for students to understand and recall in essays. The extensive use of cross-referencing makes it possible for students to return to individual sections for review purposes without difficulty. Whether students interests lie in biological, chemical, or medical aspects of biochemistry and molecular biology, Trends Biochemistry and Molecular Biology will help make students able, excited, and eager to read more widely and more deeply on this engaging subject. This important new book not only covers an extensive set of topics of current and special interest, but includes more traditional areas in biochemistry as well. Covering a wide range of topics, from classical biochemistry to proteomics and genomics, it also details the properties of commonly used biochemicals, laboratory solvents, and reagents. Coverage is expanded to include a section on stem cells, chapters on immunochemical techniques and spectroscopy techniques, and additional chapters on drug discovery and development, and clinical biochemistry. Moreover, a number of techniques used in molecular biology, for example, molecular cloning, gel electrophoresis, polymerase chain reaction, microarrays, etc. are also explained with practical examples. It also includes some of the vital pieces of work being conducted across the world, on various topics related to molecular biology. Through it, we attempt to further enlighten the readers about the new concepts in this field. Altogether, presented in an organized, concise, and simple-to-use format, Trends in Biochemistry and Molecular Biology allows quick access to the most frequently used data. There is an emphasis on biological aspects of biochemistry and new topics are introduced in their biological context wherever possible. Experimental design and the statistical analysis of data are emphasized at the end to ensure students are equipped to successfully plan their own experiments and examine the results obtained.

Advances in Clinical Chemistry

Advances in Clinical Chemistry

Advances in Clinical Chemistry, Volume 94, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest technologies relating to the field of clinical chemistry, with specific chapters in this new release covering Hypertensive disorders of pregnancy: Strategy to develop clinical peptide biomarkers for more accurate evaluation of the pathophysiological status of this syndrome, Clotting factors - Clinical biochemistry and their roles as plasma enzymes, Myokines: The endocrine coupling of skeletal muscle and bone, Epigenetic reprogramming and potential application of epigenetic-modifying drugs in acquired chemotherapeutic resistance, and more.