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Neurosciences

See below for a selection of the latest books from Neurosciences category. Presented with a red border are the Neurosciences books that have been lovingly read and reviewed by the experts at Lovereading. With expert reading recommendations made by people with a passion for books and some unique features Lovereading will help you find great Neurosciences books and those from many more genres to read that will keep you inspired and entertained. And it's all free!

Neuroethics and Nonhuman Animals

Neuroethics and Nonhuman Animals

Author: L. Syd M. Johnson Format: Hardback Release Date: 07/03/2020

This edited volume represents a unique addition to the available literature on animal ethics, animal studies, and neuroethics. Its goal is to expand discussions on animal ethics and neuroethics by weaving together different threads: philosophy of mind and animal minds, neuroscientific study of animal minds, and animal ethics. Neuroethical questions concerning animals' moral status, animal minds and consciousness, animal pain, and the adequacy of animal models for neuropsychiatric disease have long been topics of debate in philosophy and ethics, and more recently also in neuroscientific research. The book presents a transdisciplinary blend of voices, underscoring different perspectives on the broad questions of how neuroscience can contribute to our understanding of nonhuman minds, and on debates over the moral status of nonhuman animals. All chapters were written by outstanding scholars in philosophy, neuroscience, animal behavior, biology, neuroethics, and bioethics, and cover a range of issues and species/taxa. Given its scope, the book will appeal to scientists and students interested in the debate on animal ethics, while also offering an important resource for future researchers. Chapter 13 is available open access under a CC BY 4.0 license at link.springer.com.

The Wave Theory of Difference and Similarity

The Wave Theory of Difference and Similarity

Author: Stephen W. Link Format: Hardback Release Date: 04/03/2020

Two experimental procedures prompted the empirical development of psychophysical models: those that measure response frequency, often referred to as response probability; and those that measure response time, sometimes referred to as reaction time. The history of psychophysics is filled with theories that predict one or the other of these two responses. Yet the persistent reappearance of empirical relationships between these two measures of performance makes clear the need for a theory that both predicts and relates these two measures. Most likely, both response measures are the result of a single process that generates empirical laws relating response time and response probability. It is this process - its theory, description, and application - that is the topic of The Wave Theory of Difference and Similarity. Originally published in 1992, the author of this book has set out to provide a theoretical foundation for formulating new theories that systematize earlier results and to stimulate new concepts and introduce new tools for exploring mental phenomena and improving mental measurement.

How the Brain Works

How the Brain Works

Author: DK Format: Hardback Release Date: 03/03/2020

Are men's and women's brains really different? Why are teenagers impulsive and rebellious? And will it soon be possible to link our brains together via the Cloud? Drawing on the latest neuroscience research, this visual guide makes the hidden workings of the human brain simple to understand. How the Brain Works begins with an introduction to the brain's anatomy, showing you how to tell your motor cortex from your mirror neurons. Moving on to function, it explains how the brain works constantly and unnoticed to regulate heartbeat and breathing, and how it collects information to produce the experiences of sight, sound, smell, taste, and touch. The chapters that follow cover memory and learning, consciousness and personality, and emotions and communication. There's also a guide to the brain's disorders, including physical problems, such as tumours and strokes, and psychological and functional disorders, ranging from autism to schizophrenia. Illustrated with bold graphics and step-by-step artworks, and peppered with bite-sized factoids and question-and-answer features, this is the perfect introduction to the fascinating world of the human brain.

Neuroanatomy of the Mouse

Neuroanatomy of the Mouse

Author: Hannsjoerg Schroeder, Natasha Moser, Stefan Huggenberger Format: Hardback Release Date: 29/02/2020

This textbook describes the basic neuroanatomy of the laboratory mouse. The reader will be guided through the anatomy of the mouse nervous system with the help of abundant microphotographs and schemata. Learning objectives and summaries of key facts at the beginning of each chapter provide the reader with an overview on the most important information. As transgenic mice are one of the most widely used paradigms when it comes to modeling human diseases, a basic understanding of the neuroanatomy of the mouse is of considerable value for all students and researchers in the neurosciences and pharmacy, but also in human and veterinary medicine. Accordingly, the authors have included, whenever possible, comparisons of the murine and the human nervous system. The book is intended as a guide for all those who are about to embark on the structural, histochemical and functional phenotyping of the mouse's central nervous system. It can serve as a practical handbook for students and early researchers, and as a reference book for neuroscience lectures and laboratories.

fMRI

fMRI

Author: Peter A. (Chief, National Institute of Mental Health) Bandettini Format: Paperback / softback Release Date: 25/02/2020

An accessible introduction to the history, fundamental concepts, challenges, and controversies of the fMRI by one of the pioneers in the field. The discovery of functional MRI (fMRI) methodology in 1991 was a breakthrough in neuroscience research. This non-invasive, relatively high-speed, and high sensitivity method of mapping human brain activity enabled observation of subtle localized changes in blood flow associated with brain activity. Thousands of scientists around the world have not only embraced fMRI as a new and powerful method that complemented their ongoing studies but have also gone on to redirect their research around this revolutionary technique. This volume in the MIT Press Essential Knowledge series offers an accessible introduction to the history, fundamental concepts, challenges, and controversies of fMRI, written by one of the pioneers in the field. Peter Bandettini covers the essentials of fMRI, providing insight and perspective from his nearly three decades of research. He describes other brain imaging and assessment methods; the sources of fMRI contrasts; the basic methodology, from hardware to pulse sequences; brain activation experiment design strategies; and data and image processing. A unique, standalone chapter addresses major controversies in the field, outlining twenty-six challenges that have helped shape fMRI research. Finally, Bandettini lays out the four essential pillars of fMRI: technology, methodology, interpretation, and applications. The book can serve as a guide for the curious nonexpert and a reference for both veteran and novice fMRI scientists.

Tau Biology

Tau Biology

Author: Akihiko Takashima Format: Hardback Release Date: 25/02/2020

This book presents essential studies and cutting-edge research results on tau, which is attracting increasing interest as a target for the treatment of Alzheimer's disease. Tau is well known as a microtubule-associated protein that is predominantly localized in the axons of neurons. In various forms of brain disease, neuronal loss occurs, with deposition of hyperphosphorylated tau in the remaining neurons. Important questions remain regarding the way in which tau forms hyperphosphorylated and fibrillar deposits in neurons, and whether tau aggregation represents the toxic pathway leading to neuronal death. With the help of new technologies, researchers are now solving these long-standing questions. In this book, readers will find the latest expert knowledge on all aspects of tau biology, including the structure and role of the tau molecule, tau localization and function, the pathology, drivers, and markers of tauopathies, tau aggregation, and treatments targeting tau. Tau Biology will be an invaluable source of information and fresh ideas for those involved in the development of more effective therapies and for all who seek a better understanding of the biology of the aging brain.

Functional and Clinical Neuroanatomy

Functional and Clinical Neuroanatomy

Functional and Clinical Neuroanatomy: A Guide for Health Care Professionals is a comprehensive, yet easy-to read, introduction to neuroanatomy that covers the structures and functions of the central, peripheral and autonomic nervous systems. The book also focuses on the clinical presentation of disease processes involving specific structures. It is the first review of clinical neuroanatomy that is written specifically for nurses, physician assistants, nurse practitioners, medical students and medical assistants who work in the field of neurology. It will also be an invaluable resource for graduate and postgraduate students in neuroscience. With 22 chapters, including two that provide complete neurological examinations and diagnostic evaluations, this book is an ideal resource for health care professionals across a wide variety of disciplines.

Horizons in Neuroscience Research.

Horizons in Neuroscience Research.

Author: Andres Costa Format: Hardback Release Date: 20/02/2020

Physiotherapy and rehabilitation applications in neurological diseases are important for the treatment of the disease. The basic principle of physiotherapy and rehabilitation is to determine the needs of the patient. As such, the authors discuss the evaluation of the motor functions of neurological diseases for upper and lower extremities separately, as well as sensorial functions and cognitive functions. Next, a literature review draws attention to studies in which sex was a controlled variable, and presents data regarding sexual dimorphism in a range of aspects developed after brain injury. It is possible to document the accomplishments of different cell death mechanisms and varying degrees of inflammatory response depending on the sex, as well as the distinct susceptibilities of the sexes in terms of mechanisms of cell damage. Additionally, summary of techniques and indications related to cerebrovascular bypass surgery for aneurysmal subarachnoid hemorrhage cases is provided, maintaining that cerebral revascularization procedures should be further developed by neurosurgeons as they remain the only option of treatment for a significant number of patients. The authors review their extensive experience with indocyanine green video-angiography and FLOW 800 analysis software during the surgical removal of central nervous system tumors; in particular, they identified 5 possible applications of indocyanine green video-angiography and FLOW 800 in this field. Data is presented showing the reciprocity between the brain angiotensin II system and amphetamine exposure in the development and expression of behavioral, neurochemical and glial alterations. Particularly, this collection explores how the neuroadaptative responses and neuroinflammation evoked by the psychostimulant and depending on AT1 receptors that might resemble some features linked to different brain disorders. Lastly, a brief overview of the investigational history in research work on receptor/G-protein coupling is presented. Subsequently, the most recent experimental results in the re-establishment of [35S]GTPyS binding/immunoprecipitation assay are described.

Preclinical Research in Down Syndrome: Insights for Pathophysiology and Treatments

Preclinical Research in Down Syndrome: Insights for Pathophysiology and Treatments

Author: Mara (CRG-Center for Genomic Regulation, Spain) Dierssen Format: Hardback Release Date: 11/02/2020

Preclinical Research in Down Syndrome: From Bench to Bedside, Volume 251, the latest release in the Progress in Brain Research series, highlights new advances in the field. Chapters in this updated release include Exploring genetic and epigenetic mechanisms underlying cognitive deficits in Dow syndrome, The trisomy paradox: gene expression dysregulation domains, the Influence of allelic differences in mouse models of Down syndrome, Modelling Down syndrome in cells: From stem cells to organoids, Modelling Down syndrome in animals from the early stage to the new generation of models, Mapping behavioral landscapes in Down syndrome animal models, and more.

The Design of Experiments in Neuroscience

The Design of Experiments in Neuroscience

Author: Mary E. (Smith College, Massachusetts) Harrington Format: Paperback / softback Release Date: 06/02/2020

Using engaging prose, Mary E. Harrington introduces neuroscience students to the principles of scientific research including selecting a topic, designing an experiment, analyzing data, and presenting research. This new third edition updates and clarifies the book's wealth of examples while maintaining the clear and effective practical advice of the previous editions. New and expanded topics in this edition include techniques such as optogenetics and conditional transgenes as well as a discussion of rigor and reproducibility in neuroscience research. Extended coverage of descriptive and inferential statistics arms readers with the analytical tools needed to interpret data. Throughout, practical guidelines are provided on avoiding experimental design problems, presenting research including creating posters and giving talks, and using a '12-step guide' to reading scientific journal articles.

The Design of Experiments in Neuroscience

The Design of Experiments in Neuroscience

Author: Mary E. (Smith College, Massachusetts) Harrington Format: Hardback Release Date: 06/02/2020

Using engaging prose, Mary E. Harrington introduces neuroscience students to the principles of scientific research including selecting a topic, designing an experiment, analyzing data, and presenting research. This new third edition updates and clarifies the book's wealth of examples while maintaining the clear and effective practical advice of the previous editions. New and expanded topics in this edition include techniques such as optogenetics and conditional transgenes as well as a discussion of rigor and reproducibility in neuroscience research. Extended coverage of descriptive and inferential statistics arms readers with the analytical tools needed to interpret data. Throughout, practical guidelines are provided on avoiding experimental design problems, presenting research including creating posters and giving talks, and using a '12-step guide' to reading scientific journal articles.

Brain Mitochondria

Brain Mitochondria

Author: Silvia Lores-Arnaiz Format: Hardback Release Date: 04/02/2020

Brain mitochondria: Distribution and Function offers an overview of significant findings regarding physiological, toxicological and pathological aspects of brain mitochondria properties and their relevant role in cellular bioenergetics. Essential physiological processes such as cell respiration and ATP synthesis, the maintenance of calcium homeostasis, reactive oxygen species generation and apoptotic cell signaling performed by mitochondria are described in the different chapters of this volume. In particular, the importance of specific calcium signaling at synaptic level and its relationship with mitochondrial bioenergetics are extensively described. Being that high energy demands are required at synaptic level for neurotransmission, mitochondrial distribution becomes relevant for essential neuronal processes. Differential bioenergetic characteristics of neuronal, astrocytic and glial mitochondria are discussed. Interestingly, new insights on the interaction between neurotensinergic and nitrergic systems are detailed, based on experimental evidences of the effect of neurotensin receptors blockade on nitric oxide production and mitochondrial function. The chapters describing metal neurotoxicity provide a comprehensive view of the effects of different metals on brain mitochondrial function and their consequences for human health. The impact of iron and copper overload on brain oxidative redox balance and mitochondrial function is fully detailed, focusing on the role of metal-induced neuronal damage on the incidence and progression of neurodegenerative diseases. In addition, a complete revision of the mechanisms underlying heavy metal-mediated damage to brain mitochondria is presented. Neurotoxic effects of arsenic, thallium, lead, cadmium and mercury have been associated with cell bioenergetics impairment, exacerbated production of oxygen free radicals, and induction of intrinsic pathway of apoptosis. Mitochondrial function can also be impaired by treatment with different drugs acting at CNS level. The understanding of the effects of pharmacological agents, abuse drugs, herbicides and insecticides at mitochondrial level can contribute to elucidate the molecular mechanisms involved in neurodegeneration. In this context, the neuroprotective effect of different compounds targeting mitochondrial integrity and function is discussed. Furthermore, mitochondrial alterations, oxygen radicals generation and nitric oxide production are characterized in relation to CNS pathology and hypoxia conditions. Mitochondrial complex I inactivation, oxidative stress and impairment of mitochondrial nitric oxide synthesis are characteristic features of the mitochondrial dysfunction observed in Parkinson's disease and other CNS pathologies. In addition, exposure to hypoxic conditions can affect nitric oxide generation and mitochondrial physiology, with different responses depending on the brain area. As a whole, the understanding of the alterations in mitochondrial distribution and function in the brain associated with neurotoxicity and neurodegeneration may contribute to the knowledge of the role of mitochondria in maintaining the balance between health and disease.