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See below for a selection of the latest books from Medical research category. Presented with a red border are the Medical research books that have been lovingly read and reviewed by the experts at Lovereading. With expert reading recommendations made by people with a passion for books and some unique features Lovereading will help you find great Medical research books and those from many more genres to read that will keep you inspired and entertained. And it's all free!
In Advances in Medicine and Biology. Volume 138, the authors reflect on the development of ethically reliable procedures that keep in line with cultural traits while guaranteeing proper implementation of the fundamental principles of bioethics, within the framework of ethically binding biomedical research. As such, this write-up gives an overview on the ethical implications and regulatory issues governing African traditional medicine research practices in Cameroon.This collection goes on to present the relationship between riboflavins chemical properties and its exploitable applications in both living organisms and analytical assays. Riboflavin, popularly known as Vitamin B2 or Vitamin G, was historically the second identified vitamin and presents itself as a yellow solid substance, and its higher stabilization is observed at pH 5.In the following study, technological discrimination of lactic acid bacteria species isolated from fermented cereal foods available in Abidjan are presented as of interest, because these species are used as starter cultures to optimize fermented product quality. The sugar fermentation pattern and identity of twenty-three lactic acid bacteria isolates were carried out by using a ApiwebTM/Api50 CHL test kit. Protease, amylase, and bacteriocins production as well as growth parameters after 18h culture are performed.Topical naltrexone therapy has been reported to reverse diabetes complications in type 1 and type 2 animal models in an effective and non-toxic manner. Because of this, the authors discuss the mechanism of action of naltrexone, as well as data documenting its efficacy in therapy for diabetic complications, supporting the repurposing of naltrexone for clinical use.Additionally, general opioid receptor antagonists such as naltrexone that block classical opioid receptors mu, delta, and kappa are still widely used to reverse drug and alcohol overdose/use. With the discovery of the opioid growth factor receptor axis as a novel biological pathway involved in homeostasis of replicating cells and tissues, the role of opioid receptor antagonists is expanded.Syndecans are transmembrane heparan sulfate proteoglycans expressed in a variety of cells, and their heparan sulfate glycosaminoglycan side chains bind to several proteins (such as chemokine and growth factors) taking on various biological roles. Several types of proteoglycans, including syndecans in the lung as components of extracellular matrices, were previously recognized only as molecular glue that supports the structure of tissues. However, growing evidence suggests that proteoglycans have a variety of biological activities such as control of inflammation, wound healing, development and homeostasis, which the authors examine.M-type phospholipase A2 receptor is a type I transmembrane receptor and belongs to the mannose receptor family. In 2009, M-type phospholipase A2 receptor was identified as a target intrinsic antigen in most cases of primary membranous nephropathy. The authors propose that in addition, the detection of circulating anti-M-type phospholipase A2 antibodies is useful not only for the differential diagnosis of primary membranous nephropathy but also for monitoring treatment, including after renal transplantation.The most frequent familial amyloidosis presentation is due to transthyretin, a protein analyzed in the concluding chapter and originally referred to as pre-albumin. There are more than eighty transthyretin mutations, the majority being amyloidogenic. The carriers of the mutation on this protein genes show a clinical heterogeneous amyloidosis according to the nature of aminoacid substitution.
This book is an essential guide on how to conduct human medical research with a focus on the fundamental concepts of contemporary biostatistics and epidemiology. It provides an overview of all necessary steps: from setting up research, analyzing collected data and publishing results as a scientific paper and also in finding the appropriate audience for a completed study. This comprehensive but compact book covers the writing of research proposals, choosing research designs, describing collected data, and understanding various techniques of inferential statistics. It is written from an applied point-of-view: two studies are used as example, which guide the reader through all steps, focusing on the interpretation of the results using SPSS (Statistical Package for the Social Sciences) output. A Quick Guide on How to Conduct Medical Research is not only an indispensable resource for PhD students, researchers as well as physicians performing their own research, but also for any readers of medical research who would like a deeper understanding of scientific publications. It can also be used in educational programs in the school of medicine, health sciences, human movement sciences, medical biology and paramedical schools.
This extensively revised new edition comprehensively reviews the rise of clinical research informatics (CRI). It enables the reader to develop a thorough understanding of how CRI has developed and the evolving challenges facing the biomedical informatician in the modern clinical research environment. Emphasis is placed on the changing role of the consumer, and the need to merge clinical care delivery and research as part of a changing paradigm in global healthcare delivery. Clinical Research Informatics presents a detailed review of using informatics in the continually evolving clinical research environment. It represents a valuable textbook reference for all students and practising healthcare informaticians looking to learn and expand their understanding of this fast-moving and increasingly important discipline.
This book details protocols on classical methods and very modern ex vivo mammalian developmental kidney model systems. Chapters focus on generation of mosaic embryonic kidneys, culture of the kidney tissues ex vivo, embryonic kidney progenitor cell, 3Dkidney model cell line based cultures, programming the kidney cell fates in human pluripotent cells, protocols to target the functional players in kidney ontogenesis, 4D and 3D ex vivo imaging, drosphila, and computational approaches to kidney ontogenesis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Kidney Organogenesis: Methods and Protocols aims to ensure successful results in the further study of this vital field.
This book presents, in two parts, a review concerning the use of Rattus norvegicus as a model for the study of neurological disorders and oncological diseases (mammary cancer). In the first part, the neurological disorders are addressed in important neurological diseases, such as: Autism, Parkinsons, Huntingtons and Alzheimers disease, and two neuromotor dysfunctions (amyotrophic lateral sclerosis and ataxia). The second part reveals the importance of the rat as a model for the study of mammary cancer, presenting the diversity of rat strains and models available for the study of this oncological disease. This part is mainly focused on the chemically-induced models of mammary cancer and on the importance of the rat for the development of new prophylactic and therapeutic strategies to fight this disease.For many years and up to the present, rat models have allowed the study of innumerable diseases, as well as their etiology, pathogenesis, evolution and treatment. Due to this, the role of this species for the evolution of medicine is undoubtable.Since the information presented in this book was obtained from years of works of expertise in the field, we hope that it be useful for those researchers aiming to use Rattus norvegicus as a model to study human diseases, providing them with valuable information for the adequate selection and management of this species in their experiments.
The third edition of this book provides a large number of laboratory protocols that are intended for basic and clinical bone researchers. Chapters are organized into five parts covering methods for isolation, ex vivo models of bone organ and cell co-culture system, biochemical procedures, animal models of bone remodeling, and rodent models on Rheumatoid arthritis and osteoarthritis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge Bone Research Protocols: Methods and Protocols, Third Edition aims to extensive list of protocols for anyone interested in bone research.
The book contains the refereed contributions from the 45th Annual Meeting of the International Society on Oxygen Transport to Tissue (ISOTT) 2017. This volume covers cross-disciplinary work on a broad range of topics related to the dynamics of oxygen transport: microcirculation and vascular medicine; O2 deficiency and its impact on molecular processes in cells and tissues; cellular metabolism and mitochondrial function; multimodal functional imaging; mathematical modeling; the clinical relevance of oxygen supply as well as therapeutic interventions (e.g. in oncology or critical care medicine). The annual meetings of ISOTT bring together scientists from diverse fields (medicine, physiology, mathematics, biology, chemistry, physics, engineering, etc.) in a unique international forum. The book includes sections on brain oxygenation and function, NIRS oxygenation measurements, tumor oxygenation, cell metabolism, tissue oxygenation and treatment, methodical aspects of O2 measurements and physicochemical aspects of oxygen diffusion. Chapters 3, 24, 49 and 51 of this book are open access under a CC BY 4.0 license.
In the opening chapter of Advances in Medicine and Biology. Volume 135, the authors propose that to correctly interpret the results of procalcitonin accuracy studies for the diagnosis of neonatal sepsis, we must analyze the methods we use to measure procalcitonin performance. Trypanosoma cruzi is a flagellated protozoan that causes Chagas disease, also known as America Trypanosomiasis. The authors discuss techniques for diagnosis, including parasitological methods based on microscopy, xenodiagnoses and microscopic examination of fresh anticoagulated blood or buffy coat. The collection goes on to discuss rhabdomyolysis, a clinical syndrome caused by injury to skeletal muscle fibres with the release of their breakdown products, especially myoglobin, into the circulation. The condition is associated with traumatic injury, crush syndrome, extreme exercise, drugs, toxins and malignant hyperthermia among other things. In the next review, the authors intend to aid our understanding of lipid metabolism and provide a rational basis for future research in drug development by analysing current data related to the role of mutual regulation between hormone-sensitive lipase and insulin, discussing unanswered questions in different lines of studies. Following this, one study aims increase the activity of high-molecular-weight heparin through the development of a new high active heparin complex with glutamate. The thermodynamic simulation of chemical equilibria based on pH data and the molecular dynamics simulation were used. Later, the structure of two human blood groups with both AB active glycoproteins (HOC 89 and Cyst 19) isolated from human ovarian cyst fluids are introduced. Their properties are characterized by interactions with mAbs against the human blood group (ABH), Lewis system, sialyl glycotopes and various applied lectins. This collection also reviews differential diagnostic considerations to consider when making a diagnosis of malignant peripheral nerve sheath tumors in the breast. Malignant peripheral nerve sheath tumors account for approximately 5% of all soft tissue sarcomas and are associated with neurofibromatosis type I and a prior history of radiation. They are aggressive tumors with a propensity to recur and to develop distant metastases. An analysis is provided concerning the literature regarding the clinicopathologic features of epithelioid malignant peripheral nerve sheath tumors. Particular attention is paid to how this variant may be differentiated from other diagnostic considerations and on the utility of molecular testing in the evaluation of these lesions. Finnish type congenital nephrotic syndrome, also known as type 1 nephrotic syndrome (NPHS1), OMIM 256300, is caused by mutations in the nephrin gene. These mutations cause a congenital glomerulonephritis, which is particularly frequent in Finland (incidence of 1:8200 newborns). Since immunosuppressive therapy does not induce clinical remission, the authors propose that the best method of treatment is a bilateral nephrectomy and kidney transplantation. In the subsequent chapter, the effect of advanced glycation end products on renal cell in diabetic nephropathy is discussed in respect to downstream alterations such as reactive oxygen species production, activation of nicotinamide adenine dinucleotide phosphate oxidase, nuclear factor-kappa B activation, synthesis of transforming growth factor-beta 1 and fibronectin leading to epithelial to mesenchymal transition. In the concluding chapter, the potential problem of quinoline yellow as food additive is introduced, followed by detailed description of the electrochemical methods of detection. Quinoline yellow is commonly applied as a food colorant, however it may cause allergy symptoms in those allergic to aspirin and lead to severer hyperactivity in children.
The purpose of this book is to provide information which supports the fact that rat hybridomas are no more difficult to develop than mouse hybridomas. This is the first book devoted to the development of rat hybridomas. It includes theories, step-by-step techniques, ingredients and apparatus. The focus of this work is on the antibody repertoire, the unique biological properties of rat immunoglobulins, the one-step purification procedure by immunoaffinity chromatography, the absence of C-type particles, and the easy production of large amounts of ascitic fluid containing rat MAb. This rare publication is an absolute must for all scientists using MAbs and those interested in the fields of immunology, biotechnology, and biochemistry.
This book provides an overview of recent advances in the study of aging and aging related diseases, discussing the topics at individual, organ, tissue, cell, and molecular levels. It also presents studies on the biomarkers of aging and anti-aging interventions. Aging has been becoming a global health problem. However it was not possible to determine aging as we usually diagnose a disease because there are few biomarkers for age estimation. Since ancient times, people have been seeking anti-aging substances and methods for achieving immortality, while the scientific study of aging has only existed for 100 years. This book appeals to researchers both in institutes and in pharmaceutical companies interested in further studies in this field.