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Medical research

See below for a selection of the latest books from Medical research category. Presented with a red border are the Medical research books that have been lovingly read and reviewed by the experts at Lovereading. With expert reading recommendations made by people with a passion for books and some unique features Lovereading will help you find great Medical research books and those from many more genres to read that will keep you inspired and entertained. And it's all free!

Research Methods for Medical Graduates

Research Methods for Medical Graduates

This book discusses the why and how of each step of data-based medical research that can provide basic information to emerging researchers and medical graduate students who write theses or publish articles. The chapters are arranged in the sequence of steps for data-based research. The research steps are comprehensively covered from the selection of the topic to the final publication. Reporting methods such as CONSORT, STARD, and SAMPL guidelines are also covered. Each chapter has separately earmarked examples from the contemporary literature that illustrate the different research methods. Key Features Discusses all the steps of data-based medical research Examines the topics in depth by way of examples from contemporary literature Features notable information in boxes for special attention .

Clinical Research Transformed

Clinical Research Transformed

Author: Olli S. Miettinen, Johann Steurer, Albert Hofman Format: Hardback Release Date: 28/10/2019

In this Information Age, the practices of clinical medicine should no longer be based on what clinical doctors actively know. Rather, all of the importantly practice-relevant knowledge should not only already exist but also be codified in cyberspace, in directly practice-guiding 'expert systems' -- for the benefit of both doctors and patients everywhere. Each of these systems (discipline-specific) would, prompted by a particular type of case presentation, present the doctor a questionnaire specific to cases of the type at issue, and document the doctor's answers to the questions. If at issue would be a case of complaint about a (particular type of) sickness, the system would translate the resulting diagnostic profile of the case into the corresponding probabilities of the illnesses to be considered. Similarly, if at issue would be an already-diagnosed case of a particular illness, the system would ask about, and record, the relevant elements in the prognostic profile of the case and then translate this profile into the probabilities of various outcomes to be considered, probabilities specific to the choice of treatment and prospective time in addition to that profile. And besides, these systems would analogously address the causal origin -- etiogenesis -- of cases of particular types of illness. While the requisite knowledge-base for these systems -- notably for the probabilities in them -- has not been addressed by such 'patient-oriented' clinical research as has been conducted (very extensively) up to now, this book delineates the nature of the suitably-transformed research (gnostic). The critically-transformative innovation in the research is the studies' focus on Gnostic Probability Functions -- dia-, etio-, and prognostic -- in the framework of logistic regression models. This book also presents a vision of how this critically-transformative research would most expeditiously be provided for and also conducted, among select sets of academic teaching hospitals.

Reviews in Plasmonics 2017

Reviews in Plasmonics 2017

Author: Chris D. Geddes Format: Hardback Release Date: 24/10/2019

Reviews in Plasmonics is a comprehensive collection of current trends and emerging hot topics in the field of Plasmonics and closely related disciplines. It summarizes the years progress in Plasmonics and its applications, with authoritative analytical reviews specialized enough to be attractive to professional researchers, yet also appealing to the wider audience of scientists in related disciplines of Plasmonics.

Lymphatic Structure and Function in Health and Disease

Lymphatic Structure and Function in Health and Disease

Lymphatic Structure and Function in Health and Disease serves as a resource book on what has been learned about lymphatic structure, function and anatomy within different organ systems. This is the first book to bring together lymphatic medicine as a whole, with in-depth analysis of specific aspects of lymphatics in different vascular pathologies. This book is a useful tool for scientists, practicing clinicians and residents, in particular, those in vascular biology, neurology, cardiology and general medicine. Chapters discuss topics such as ontogeny and phylogeny of lymphatics, lymphatic pumping, CNS lymphatics, lymphatics in transplant and lymphatic reconstruction.

Meta-analysis of Binary Data Using Profile Likelihood

Meta-analysis of Binary Data Using Profile Likelihood

Author: Dankmar Bohning, Sasivimol Rattanasiri, Ronny Kuhnert Format: Paperback / softback Release Date: 21/10/2019

Providing reliable information on an intervention effect, meta-analysis is a powerful statistical tool for analyzing and combining results from individual studies. Meta-Analysis of Binary Data Using Profile Likelihood focuses on the analysis and modeling of a meta-analysis with individually pooled data (MAIPD). It presents a unifying approach to modeling a treatment effect in a meta-analysis of clinical trials with binary outcomes. After illustrating the meta-analytic situation of an MAIPD with several examples, the authors introduce the profile likelihood model and extend it to cope with unobserved heterogeneity. They describe elements of log-linear modeling, ways for finding the profile maximum likelihood estimator, and alternative approaches to the profile likelihood method. The authors also discuss how to model covariate information and unobserved heterogeneity simultaneously and use the profile likelihood method to estimate odds ratios. The final chapters look at quantifying heterogeneity in an MAIPD and show how meta-analysis can be applied to the surveillance of scrapie. Containing new developments not available in the current literature, along with easy-to-follow inferences and algorithms, this book enables clinicians to efficiently analyze MAIPDs.

Genetics of Endocrine Diseases and Syndromes

Genetics of Endocrine Diseases and Syndromes

Author: Peter Igaz Format: Hardback Release Date: 17/10/2019

This book provides a comprehensive overview of the genetic basis underlying endocrine diseases. It covers both the molecular and clinical consequences of these genetic defects, as well as the relevance for clinical care, highlighting issues of genetic counseling. Several endocrine diseases have a genetic background, and contemporary research in the field plays a crucial role in the clinical care of endocrine diseases. In recent years, there have been major developments in our understanding of the genetic basis of endocrine diseases. Several novel genes and mutations predisposing individuals to monogenic endocrine diseases have been discovered, and with the advent of next generation sequencing, a huge amount of new data has become available. Further, novel molecular mechanisms, such as genomic imprinting, have been implicated in the pathogenesis of endocrine diseases. A better understanding of the genetic background of these diseases is relevant not only from the research perspective, but also in terms of clinical care. As such, this book is an essential read for both researchers and clinicians working in the field.

Neuroprotection in Autism, Schizophrenia and Alzheimer's disease

Neuroprotection in Autism, Schizophrenia and Alzheimer's disease

Neuroprotection in Autism, Schizophrenia and Alzheimer's Disease provides an up-to-date overview on recent clinical studies and the similarities discovered in the most prevalent brain disorders. The book's content will help shed light on basic mechanisms and provide new avenues for early diagnosis toward disease prevention and disease modification. It is written for researchers, clinicians and medical physicians in neuroscience, neurology and psychiatry. Sections discuss the shared pathophysiological mechanisms that underlie autism, schizophrenia/mood disorders and Alzheimer's disease, i.e. neurodevelopmental disorders, neuropsychiatric diseases and neurodegenerative disorders.

Mastitis Symptoms, Triggers and Treatment

Mastitis Symptoms, Triggers and Treatment

Author: Tapas Kumar Sar Format: Hardback Release Date: 10/10/2019

Mastitis is the most widespread and economically important disease of dairy cattle occurring throughout the world. It is of particular concern for farmers in developing countries like India. The economic loss due to mastitis is associated with reduced milk production, discard of milk due to antibiotic residues, treatment and management costs, and occasional deaths. The menace has a serious zoonotic threat due to shedding of bacteria and their toxins through the milk. Mastitis is caused by a wide spectrum of pathogens and, it is categorized into contagious and environmental mastitis. The major contagious pathogens include Staphylococcus aureus, Streptococcus agalactiae, Mycoplasma spp. and Corynebacterium bovis. The environmental mastitis can be induced by those pathogens residing in the environment such as E. coli, Klebsiella spp., Streptococcus dysgalactiae and Streptococcus uberis. On the basis of symptoms, mastitis can be classified into either clinical or sub-clinical. Clinical mastitis is characterized by sudden onset, alterations of milk composition and appearance, decreased milk production, and the presence of the cardinal signs of inflammation in the udder. In contrast, in sub-clinical mastitis, no cardinal signs are detected although the milk production is decreased and the somatic cell count is increased. The diagnosis of sub-clinical mastitis is a real challenge in the dairy industry. The book contains a total of 7 chapters including a research chapter (chapter 6) for control of mastitis, a global problem with public health menace. Persons associated with antimicrobial stewardship and drug control policies may go through chapters 5 and 7 for getting some suggestions and clarifications for their consideration. The use of propolis for mastitis control is an innuendo for the reduction of antimicrobial misuse. Antimicrobial resistance (AMR) in pathogens isolated from ewes and goats with mastitis has been recorded. This approach is in line with the antimicrobial stewardship, with the aim of limiting the selection for antimicrobial resistant strains. Propolis ethanol extracts showed a good bactericidal activity against mastitis pathogens as well as the capacity to inhibit biofilm formation and to disrupt established biofilm. These results strongly suggest that propolis may be part of a mastitis control strategy. The present book is a comprehensive attempt to cover the relevant topics of bovine mastitis such as physiology of milk secreation with associated biomarkers, immune responses of udder, updated etiology, current trends in conventional treatment and management, prospect of herbal preparations and propolis as supportive treatment options. The book will cater the need of the veterinary/dairy science/one health students, professionals, researchers and moreover, the progressive farmers who wish to understand the basics of the menace. Any suggestions from any corner for the improvement of the book will be gladly acknowledged.

Integrated Drug Discovery Technologies

Integrated Drug Discovery Technologies

Author: Houng-Yau Mei, Anthony W. Czarnik Format: Paperback / softback Release Date: 07/10/2019

Integrated Drug Discovery Technologies provides a global overview of emerging drug development technologies by presenting and integrating new techniques from the disciplines of chemistry, biology, and computational sciences. It combines integration of contemporary mechanization with strategies in drug delivery. Topics include: functional genomics, microfabrication techniqes, integrated proteomics technologies, high throughput screening, and fluorescence correlation spectroscopy methods.

Project Management of Clinical Trials

Project Management of Clinical Trials

Author: Richard Chamberlain Format: Hardback Release Date: 24/09/2019

Project Management of Clinical Trials

Project Management of Clinical Trials

Author: Richard Chamberlain Format: Paperback / softback Release Date: 24/09/2019

Bioactive Ceramides in Health and Disease Intertwined Roles of Enigmatic Lipids

Bioactive Ceramides in Health and Disease Intertwined Roles of Enigmatic Lipids

Author: Johnny Stiban Format: Hardback Release Date: 20/09/2019

This book is about the various roles of bioactive ceramides and other sphingolipids in cellular biology. The enigmatic biophysical and biochemical properties of ceramides and their propensity to influence membranes whether as rafts or protein-permeable channels are heavily discussed. Metabolism of ceramides and their metabolites is also focused with ceramide synthase family of proteins being a target of extensive review. Ceramide 1-phosphate and other sphingolipids are also presented in cellular physiology and pathophysiology. Prokaryotic origins of mitochondria at the level of membranes and the occurrence of apoptosis in bacteria are presented. Many aspects of ceramide and sphingolipid biology are addressed in this book. Its focus is the metabolism of ceramide in normal and diseased states and the biophysical and biochemical mechanisms governing the bioactivity of these molecules. Sphingolipid research has surged over the past thirty years and this book gathers the recent findings of various aspects of sphingolipid biochemistry. World-renowned scientists from the field of lipid biology, specifically sphingolipid biochemistry, were gathered to write this book. Scholars from most continents of the globe committed to write diligently about their expertise and the newest findings in the relevant fields. This book came to fruition after almost a year and a half of laborious preparation and diligent writings. This book is targeted to the experienced reader who is looking to read about the various aspects of bioactive ceramide signaling, as well as to the newcomer into the field, as the topics are explained in concise yet very informative manner. The authors and editor wish all readers a pleasant time reading this volume, and are adamant that this book will meet all expectations.