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Selective Heat Sensitivity of Cancer Cells by A. Rossi Fanelli

Selective Heat Sensitivity of Cancer Cells

Part of the Recent Results in Cancer Research Series


Selective Heat Sensitivity of Cancer Cells by A. Rossi Fanelli

Since the first observations of Busch in 1866, the possible use of heat as a therapeutic agent in the cure of cancer has been repeatedly subject to bursts of interest, almost invariably followed by periods of neglect and skepticism. In 1963-1964, this problem was again attacked by us both from the biochemical and from the clinical points of view. The first results of this joint effort were positive beyond expectation, and generated a new revial of studies aimed at the identification of the nature of the bio- chemical lesion as well as at the optimization of technique and of the therapeutic schedules connected with clinical use. Although the number of mammalian tumors which have been proved to be heat-sensitive is now relatively large, and although in some cases a correlation has been demonstrated between tumorigenicity and heat-sensitivity of in vitro cultured cell lines, the question of a direct and constant relationship between neoplastic character and higher sensitivity to hyperthermic exposure is still open to continuing investigation and reappraisal. Several studies deal in fact with the determination of the conditions under which, in vitro and or in vivo, different tumors are efficiently damaged by elevated temperatures.

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Book Info

Publication date

21st December 2011


A. Rossi Fanelli

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Springer-Verlag Berlin and Heidelberg GmbH & Co. K an imprint of Springer-Verlag Berlin and Heidelberg GmbH & Co. KG


192 pages


Cellular biology (cytology)



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