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This reference work presents the origins of cells for tissue engineering and regeneration, including primary cells, tissue-specific stem cells, pluripotent stem cells and trans-differentiated or reprogrammed cells. There is particular emphasis on current understanding of tissue regeneration based on embryology and evolution studies, including mechanisms of amphibian regeneration. The book covers the use of autologous versus allogeneic cell sources, as well as various procedures used for cell isolation and cell pre-conditioning , such as cell sorting, biochemical and biophysical pre-conditioning, transfection and aggregation. It also presents cell modulation using growth factors, molecular factors, epigenetic approaches, changes in biophysical environment, cellular co-culture and other elements of the cellular microenvironment. The pathways of cell delivery are discussed with respect to specific clinical situations, including delivery of ex vivo manipulated cells via local and systemic routes, as well as activation and migration of endogenous reservoirs of reparative cells. The volume concludes with an in-depth discussion of the tracking of cells in vivo and their various regenerative activities inside the body, including differentiation, new tissue formation and actions on other cells by direct cell-to-cell communication and by secretion of biomolecules.
|Publication date:||29th October 2020|
|Author:||Jeffrey M. Gimble|
|Publisher:||Springer International Publishing AG|
|Categories:||Biomedical engineering, Materials science, Biotechnology, Cellular biology (cytology), Biophysics, Medical physics,|
Dr. Gimble is co-founder and Chief Scientific Officer of LaCell LLC and Obatala Sciences Inc. For over 30 years, Dr. Gimble's laboratory has focused on stromal/stem cells isolated from bone marrow and adipose tissue as a model system for differentiation, hematopoiesis, metabolism, and regenerative medicine. Over this period, he has held faculty appointments (full time or adjunct) at the Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Baylor College of Medicine, University of North Carolina Chapel Hill, Duke University Medical Center, Louisiana State University Health Science Center-New Orleans, and Tulane University Center for Stem Cell Research and Regenerative ...More About Jeffrey M. Gimble