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Treatment and Prevention of Malaria Antimalarial Drug Chemistry, Action and Use by Henry M. Staines

Treatment and Prevention of Malaria Antimalarial Drug Chemistry, Action and Use

Part of the Milestones in Drug Therapy Series


Treatment and Prevention of Malaria Antimalarial Drug Chemistry, Action and Use by Henry M. Staines

Malaria has defeated previous efforts at eradication and remains a massive global public health problem despite being readily preventable and treatable. It is a devastating disease that also extracts huge economic costs from the poorest countries in endemic regions. Starting with an overview of the disease and its current political, financial and technical context, this Milestones in Drug Therapy volume describes the history, chemistry, mechanisms of action and resistance, preclinical and clinical use, pharmacokinetics and safety and tolerability of the current range of antimalarial drugs. There is particular emphasis on artemisinins and related peroxides, as these drugs have now become the frontline treatment for malaria. Next generation antimalarials, molecular markers for detecting resistance, the importance of diagnostics and disease prevention are also covered in detail.


From the reviews:

Staines and Krishna successfully captures the essence of what we know about antimalarials at the beginning of the second decade of the 21st century. ... the book is a welcome and highly valuable documentation on where we stand and offers valuable food for thought in the search for the way forward. (Martin P. Grobusch, Trends in Parasitology, September, 2012)

About the Author

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Book Info

Publication date

22nd February 2014


Henry M. Staines

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Springer Basel


318 pages


Infectious & contagious diseases
Medical parasitology



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