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New Horizons in Predictive Toxicology Current Status and Application

by Ann Richard

Part of the Drug Discovery Series

New Horizons in Predictive Toxicology Current Status and Application Synopsis

Modelling and simulation technologies have improved dramatically over the past decade and their applications in toxicity prediction and risk assessment are of great importance. Such approaches will become increasingly necessary as industrial chemicals advance and as new pharmaceuticals enter the market. In this comprehensive discussion of predictive toxicology and its applications, leading experts express their views on the technologies currently available and the potential for future developments. The book covers a wide range of topics including the in silico, in vitro and in vivo approaches being used in the safety assessment of chemical substances. It reflects the growing and urgent need to strengthen our ability to predict the risks posed by industrial and pharmaceutical chemicals in humans. Extensive information on the use of current animal models used for various toxicities and target-mediated toxicities is included. Also discussed are the recently introduced regulatory initiatives.

Book Information

ISBN: 9781849730518
Publication date: 25th November 2011
Author: Ann Richard
Publisher: Royal Society of Chemistry
Format: Hardback
Pagination: 732 pages
Categories: Pharmaceutical technology, Medical toxicology,

About Ann Richard

Alan G. E. Wilson, PhD, ATS, is currently Vice President of Drug Metabolism, Pharmacokinetics, and Toxicology and Pathology at Lexicon Pharmaceuticals. He is internationally-recognized in drug metabolism, pharmacokinetics and toxicology and has over 25 years of experience working on product discovery and development for both small molecules and biotherapeutics. He has significant hands-on experience with the regulatory and GLP requirements for the conduct of ADME, PK and safety assessment studies to support regulatory submissions and clinical studies. Prior to joining Lexicon, Dr. Wilson held senior management and leadership positions with major international pharmaceutical and life science companies. He has been involved ...

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