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The Serotonin Receptors From Molecular Pharmacology to Human Therapeutics by Bryan L. Roth
  

The Serotonin Receptors From Molecular Pharmacology to Human Therapeutics

Part of the The Receptors Series

Synopsis

The Serotonin Receptors From Molecular Pharmacology to Human Therapeutics by Bryan L. Roth

A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.

Reviews

From the reviews:

This is a compilation of reviews regarding various aspects of serotonin receptor structure and function. ... As a set of reviews, the book can be read by a broad scientific audience. Material of interest to senior scientists and research fellows is present. ... Investigators wishing an up-to-date review of this field will find this book valuable. Those with selected interest, whether evolutionary or structural, will also find useful material. ... is a good, comprehensive set of reviews. ... overall, it is a valuable book. (Eugene A Davidson, Doody's Review Service, February, 2007)


About the Author

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Book Info

Publication date

28th October 2010

Author

Bryan L. Roth

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Publisher

Humana Press Inc.

Format

Paperback
618 pages

Categories

Pharmacy / dispensing

ISBN

9781617376474

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