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The Molecular Chaperones Interaction Networks in Protein Folding and Degradation by Walid A Houry

The Molecular Chaperones Interaction Networks in Protein Folding and Degradation

Part of the Interactomics and Systems Biology Series


The Molecular Chaperones Interaction Networks in Protein Folding and Degradation by Walid A Houry

Molecular chaperones are a fundamental group of proteins that have been identified only relatively recently. They are key components of a protein quality machinery in the cell which insures that the folding process of any newly-synthesized polypeptide chain results in the formation of a properly folded protein and that the folded protein is maintained in an active conformation throughout its functional lifetime. Molecular chaperones have been shown to play essential roles in cell viability under both normal and stress conditions. Chaperones can also assist in the unfolding and degradation of misfolded proteins and in disaggregating preformed protein aggregates. Chaperones are also involved in other cellular functions including protein translocation across membranes, vesicle fusion events, and protein secretion. In recent years, tremendous advances have been made in our understanding of the biology, biochemistry, and biophysics of function of molecular chaperones. In addition, recent technical developments in the fields of proteomics and genomics allowed us to obtain a global view of chaperone interaction networks. Finally, there is now a growing interest in the role of molecular chaperones in diseases. This book will provide a comprehensive analysis of the structure and function of the diverse systems of molecular chaperones and their role in cell stress responses and in diseases from a global network perspective.

About the Author

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Book Info

Publication date

10th September 2016


Walid A Houry

More books by Walid A Houry
Author 'Like for Like'


Springer-Verlag New York Inc.


485 pages


Life sciences: general issues
Medical research



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