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Book chapters are authored by participants in the International Meeting on Staging Neuropsychiatric Disorders: Implications for Etiopathogenesis and Treatment, held in Mojacar (Almeria) Spain from 14-18 October 2009. Chapters are organized into four sections on themes encompassed by Staging Neuropsychiatric Disorders: 1) Clinical Staging in the Pathophysiology of Psychotic and Affective Disorders, 2) Staging Perspectives in Neurodevelopmental Aspects of Neuropsychiatry, 3) Epigenetics and Biomarkers in the Staging of Neuropsychiatric Disorders, and 4) Staging Neurodegenerative Disorders. This volume should serve as a resource for physicians and neuroscientists alike, highlighting the importance of staging neuropsychiatric disorders and the underlying mechanistic dysfunction, for prevention and treatment strategies at different stages of disease progression.