twitter rebus 30th anniversary
Search our site
Are You Sleeping by Kathleen Barber Read the opening extract of the brand new Kathleen Barber book before its publication on 27/12/2017

Protein Folding, Misfolding and Aggregation Classical Themes and Novel Approaches by Victor Munoz

Protein Folding, Misfolding and Aggregation Classical Themes and Novel Approaches

Part of the RSC Biomolecular Sciences Series


Protein Folding, Misfolding and Aggregation Classical Themes and Novel Approaches by Victor Munoz

Protein folding and aggregation is the process by which newly synthesized proteins fold into the specific three-dimensional structures defining their biologically active states. It has always been a major focus of research in biochemistry and has often been seen as the unsolved second part of the genetic code. In the last 10 years we have witnessed a quantum leap in the research in this exciting area. Computational methods have improved to the extent of making possible to simulate the complete folding process of small proteins and the early stages of protein aggregation. Experimental methods have evolved to permit resolving fast processes of folding reactions and visualizing single molecules during folding. The findings from these novel experiments and detailed computer simulations have confirmed the main predictions of analytical theory of protein folding. In summary, protein folding research has finally acquired the status of a truly quantitative science, paving the way for more exciting developments in the near future. This unique book covers all the modern approaches and the many advances experienced in the field during the last 10 years. There is also much emphasis on computational methods and studies of protein aggregation which have really flourished in the last decade. It includes chapters in the areas that have witnessed major developments and are written by top experts including:computer simulations of folding, fast folding, single molecule spectroscopy, protein design, aggregation studies (both computational and experimental). Readers will obtain a unique perspective of the problems faced in the biophysical study of protein conformational behaviour in aqueous solution and how these problems are being solved with a multidisciplinary approach that combines theory, experiment and computer simulations. Protein Folding, Misfolding and Aggregation Classical Themes and Novel Approaches is essential reading for graduate students actively involved in protein folding research, other scientists interested in the recent progress of the field and instructors revamping the protein folding section of their biochemistry and biophysics courses.


As a whole, the book is strongly focused on current conceptual and theoretical thinking of protein folding. will appeal more to academic scientists involved in fundamental studies. * JACS, Vol 130, No 52, 2008 *

About the Author

Victor Mu+/-oz is Associate Professor in Chemistry and Biochemistry at the University of Maryland, USA and Research Professor in Biophysics at the Spanish Research Council (CSIC), Madrid, Spain. He has worked in the area of protein folding and aggregation for the last 16 years and for the last 7 years he has been involved in promoting a change from the classical biochemical to a physical paradigm in experimental protein folding.

More books by this author
Author 'Like for Like' recommendations

Loading other formats...

Book Info

Publication date

1st June 2008


Victor Munoz

More books by Victor Munoz
Author 'Like for Like'


Royal Society of Chemistry


288 pages


Spectrum analysis, spectrochemistry, mass spectrometry
Thermochemistry & chemical thermodynamics



It is a website dedicated to those who adore reading It really is a one stop shop for book lovers. Love it!

Edel Waugh

Books of the month/debuts of the month, kids/adults, fiction/non-fiction, free prize draws and free extracts, what's not to love?

Emma Smith

It's information about new books so, for a book lover like me, what's not to like!

Joan Hill

Lovereading is not only an amazing site, but it's one of my very favourites. It's like visiting a fascinating bookstore, but better.

Rebecca Jayne Barrett

Lovereading always comes up with great suggestions and has introduced me to enjoyable books and new authors to discover.

Gaynor Passmore

I 'Lovereading' because it lets me see what new books are around with a detailed synopsis and readers' reviews.

Judith Sharp

As for why I'd recommend Lovereading, it's simple - it's a great place to get information and reviews about new books!

Margaret Freeman

Lovereading is an amazing place to be, the website is wonderful and to me if I'm sad I'll go here and it cheers me up!

Sophia Upton