From the author of the acclaimed The Epigenetics Revolution comes another thrilling exploration of the cutting edge of human science.
For decades after the structure of DNA was identified, scientists focused purely on genes, the regions of the genome that contain codes for the production of proteins. Other regions - 98% of the human genome - were dismissed as 'junk'. But in recent years researchers have discovered that variations in this 'junk' DNA underlie many previously intractable diseases, and they can now generate new approaches to tackling them. Nessa Carey explores the incredible story behind a controversy that has generated unusually vituperative public exchanges between scientists. She shows how junk DNA plays an important role in areas as diverse as genetic diseases, viral infections, sex determination in mammals, human biological complexity, disease treatments, even evolution itself - and reveals how we are only now truly unlocking its secrets, more than half a century after Crick and Watson won their Nobel prize for the discovery of the structure of DNA in 1962.
"A cutting-edge, exhaustive guide to the rapidly changing, ever-more mysterious genome" -NEW SCIENTIST
Nessa Carey's THE EPIGENETICS REVOLUTION looks at how modern biology is rewriting our understanding of genetics, disease and inheritance.
At the beginning of this century, enormous progress had been made in genetics. The Human Genome Project finished sequencing human DNA. It seemed it was only a matter of time until we had all the answers to the secrets of life on this planet. The cutting-edge of biology, however, is telling us we still don't even know all the questions. The Epigenetics Revolution traces the thrilling path that epigenetics has taken over the last twenty years. Biologist Nessa Carey deftly explains such diverse phenomena as how queen bees control their colonies, why tortoiseshell cats are always female and why we age, develop disease and become addicted to drugs. Most excitingly, Carey reveals the amazing possibilities for humankind that epigenetics offers for us all.
"A book that would have had Darwin swooning - anyone seriously interested in who we are and how we function should read this." GUARDIAN
Just 45 years ago, the age of gene modification was born. Researchers could create glow-in-the-dark mice, farmyard animals producing drugs in their milk, and vitamin-enhanced rice that could prevent half a million people going blind every year.
But now GM is rapidly being supplanted by a new system called CRISPR or ‘gene editing’. Using this approach, scientists can manipulate the genes of almost any organism with a degree of precision, ease and speed that we could only dream of ten years ago.
But is it ethical to change the genetic material of organisms in a way that might be passed on to future generations? If a person is suffering from a lethal genetic disease, is it even more unethical to deny them this option? Who controls the application of this technology, when it makes ‘biohacking’—perhaps of one’s own genome—a real possibility?
Nessa Carey’s book is a thrilling and timely snapshot of a technology that will radically alter our futures.
Epigenetics can potentially revolutionize our understanding of the structure and behavior of biological life on Earth. It explains why mapping an organism's genetic code is not enough to determine how it develops or acts and shows how nurture combines with nature to engineer biological diversity. Surveying the twenty-year history of the field while also highlighting its latest findings and innovations, this volume provides a readily understandable introduction to the foundations of epigenetics. Nessa Carey, a leading epigenetics researcher, connects the field's arguments to such diverse phenomena as how ants and queen bees control their colonies; why tortoiseshell cats are always female; why some plants need cold weather before they can flower; and how our bodies age and develop disease. Reaching beyond biology, epigenetics now informs work on drug addiction, the long-term effects of famine, and the physical and psychological consequences of childhood trauma. Carey concludes with a discussion of the future directions for this research and its ability to improve human health and well-being.
